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C0888

Sigma-Aldrich

Clostripain from Clostridium histolyticum

≥20 units/mg solid

Synonym(s):

Clostridiopeptidase B, Proteinase from Clostridium histolyticum

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100 μG
CN¥4,220.99

CN¥4,220.99

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100 μG
CN¥4,220.99

About This Item

CAS Number:
9028-00-6
EC Number:
3.4.22.8 (BRENDA, IUBMB)
EC Number:
232-822-2
MDL number:
MFCD00130814
UNSPSC Code:
12352204
NACRES:
NA.54

CN¥4,220.99

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form

lyophilized powder

specific activity

≥20 units/mg solid

mol wt

15.4 kDa
 41.7 kDa

impurities

salt, essentially free

storage temp.

2-8°C

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This Item
PHR14167140925116
柠檬酸钠 二水合物 meets USP testing specifications

S1804

柠檬酸钠 二水合物

柠檬酸钠 Pharmaceutical Secondary Standard; Certified Reference Material

PHR1416

柠檬酸钠

柠檬酸钠三盐基 二水合物 tested according to Ph. Eur.

71409

柠檬酸钠三盐基 二水合物

柠檬酸钠三盐基 二水合物 puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E331, 99-100.5% (calc. to the dried substance)

25116

柠檬酸钠三盐基 二水合物

Quality Level

300

Quality Level

300

Quality Level

100

Quality Level

200

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

form

powder

form

-

form

powder

form

-

pH

7.5-9 (25 °C, 29.4 g/L)

pH

-

pH

-

pH

7.5-9.0 (20 °C, 5%)

agency

meets USP testing specifications

agency

traceable to USP 1613859

agency

USP/NF, tested according to Ph. Eur.

agency

-

Application

Clostripain from Clostridium histolyticum has been used as a proteolytic enzyme in perfusate to detect its effect on tube hematocrit.[1] It has also been used in limited proteolysis of DNA polymerase (gp43) of phage T4 (RB69 gp43).[2]

Biochem/physiol Actions

Clostripain from Clostridium histolyticum is composed of two polypeptide chains, with molecular masses of 41.7 kDa and 15.4 kDa. Clostripain has a highly restricted substrate specificity for Arg-Xaa peptide bonds. Therefore, clostripain has been explored as a potential enzyme for protein sequencing purposes. It has also been studied as a catalyst for condensation of pharmaceutically important peptides containing Arg-Pro bonds.[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Quality

Purified, essentially salt-free

Unit Definition

One unit will hydrolyze 1.0 μmole of BAEE per min at pH 7.6 at 25 °C in the presence of 2.5 mM DTT.

Analysis Note

The enzyme must be activated for 2-3 hours before use by dissolving in 2.5 mM dithiothreitol containing 1.0 mM calcium acetate.

inhibitor

Product No.
Description
Pricing

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H334,H335

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCK2455
    BCCJ2943
    BCCH9520
    BCCH4761
    BCCG5867

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    Synthesis of neo-peptidoglycans: an unexpected activity of proteases.
    Nicole Wehofsky et al.
    Angewandte Chemie (International ed. in English), 41(15), 2735-2738 (2002-08-31)
    Heparinase treatment suggests a role for the endothelial cell glycocalyx in regulation of capillary hematocrit
    Desjardins C and Duling BR
    The American Journal of Physiology, 258, H647-H654 (1990)
    all-D-Polypeptides: novel targets for semisynthesis.
    Nicole Wehofsky et al.
    Angewandte Chemie (International ed. in English), 42(6), 677-679 (2003-02-08)
    K Guzik et al.
    Cell death and differentiation, 14(1), 171-182 (2006-04-22)
    The recognition of phosphatidylserine (PS) on the surface of any apoptotic cell is considered to be a key event for its clearance. We challenge this concept by showing that pretreatment of neutrophils with either host or bacterial protease affects their
    Nicholas J Carruthers et al.
    European journal of pharmacology, 555(2-3), 106-114 (2006-12-05)
    Calcineurin, the Ca2+/calmodulin-dependant serine/threonine phosphatase is the target for the immunosuppressant drugs FK506 and cyclosporine-A. These established calcineurin inhibitors each require an immunophilin protein cofactor. Gossypol, a polyphenol produced by the cotton plant, inhibits calcineurin (IC50=15 microM), in a noncompetitive
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