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B9385

Sigma-Aldrich

Boc-Val-Pro-Arg-7-amido-4-methylcoumarin hydrochloride

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100 μG
CN¥4,622.99

CN¥4,622.99

Estimated to ship onMay 12, 2025Details

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100 μG
CN¥4,622.99

About This Item

Empirical Formula (Hill Notation):
C31H45N7O7
CAS Number:
70375-24-5
Molecular Weight:
627.73
MDL number:
MFCD00058181
UNSPSC Code:
12352204
PubChem Substance ID:
24892134
NACRES:
NA.32

CN¥4,622.99

Estimated to ship onMay 12, 2025Details

Assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

water: 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cl.CC(C)C(NC(=O)OC(C)(C)C)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C31H45N7O7.ClH/c1-17(2)25(37-30(43)45-31(4,5)6)28(42)38-14-8-10-22(38)27(41)36-21(9-7-13-34-29(32)33)26(40)35-19-11-12-20-18(3)15-24(39)44-23(20)16-19;/h11-12,15-17,21-22,25H,7-10,13-14H2,1-6H3,(H,35,40)(H,36,41)(H,37,43)(H4,32,33,34);1H

InChI key

ROQGJTZGLVLVIN-UHFFFAOYSA-N

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Anti-PR (Progesterone Receptor) antibody, Rabbit monoclonal

Anti-Progesterone Receptor antibody produced in rabbit affinity isolated antibody

SAB4502185

Anti-Progesterone Receptor antibody produced in rabbit

Anti-PGR antibody produced in rabbit Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

HPA004751

Anti-PGR antibody produced in rabbit

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Gene Information

human ... PGR(5241)

Gene Information

human ... PGR(5241)

Gene Information

human ... PGR(5241)

Gene Information

human ... PGR(5241)

clone

488/H3, monoclonal

clone

RM357, monoclonal, recombinant monoclonal

clone

polyclonal

clone

polyclonal

biological source

mouse

biological source

-

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

General description

Boc-Val-Pro-Arg-AMC serves as a synthetic substrate for human kallikrein 8.[1]

Application

Boc-Val-Pro-Arg-7-amido-4-methylcoumarin hydrochloride has been used:
  • as a fluorogenic substrate for thrombin in inhibitory assay with salivary protein cE5[2]
  • as a fluorogenic substrate for thrombin in inhibitory assay with recombinant E. nipponicum serpin[3]
  • as a substrate in proteinase assay with hemolymph protein[4]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrates

A fluorogenic substrate for thrombin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCM4330
    BCCL2939
    BCCK3625
    BCCH2497
    BCCG1065

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    Tadaaki Kishi et al.
    Biological chemistry, 387(6), 723-731 (2006-06-28)
    Human kallikrein 8 (hK8), whose gene was originally cloned as the human ortholog of a mouse brain protease, is known to be associated with diseases such as ovarian cancer and Alzheimer's disease. Recombinant human pro-kallikrein 8 was activated with lysyl
    Luciano Pirone et al.
    The Journal of biological chemistry, 292(30), 12632-12642 (2017-06-09)
    Saliva of blood-feeding arthropods carries several antihemostatic compounds whose physiological role is to facilitate successful acquisition of blood. The identification of novel natural anticoagulants and the understanding of their mechanism of action may offer opportunities for designing new antithrombotics disrupting
    Jantiwan Sutthangkul et al.
    The Journal of biological chemistry, 290(10), 6470-6481 (2015-01-13)
    The melanization cascade, activated by the prophenoloxidase (proPO) system, plays a key role in the production of cytotoxic intermediates, as well as melanin products for microbial sequestration in invertebrates. Here, we show that the proPO system is an important component
    Pavel Roudnický et al.
    Parasite (Paris, France), 25, 61-61 (2018-12-06)
    Serpins are a superfamily of serine peptidase inhibitors that participate in the regulation of many physiological and cell peptidase-mediated processes in all organisms (e.g. in blood clotting, complement activation, fibrinolysis, inflammation, and programmed cell death). It was postulated that in
    Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.
    R Lottenberg et al.
    Methods in enzymology, 80 Pt C, 341-361 (1981-01-01)
    View All Related Papers

    Protocols

    Thrombin from Bovine Plasma

    Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

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