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Merck
CN

B2805

BMP6, human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonym(s):

Bone Morphogenetic Protein 6 human, BMP-6

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD02097809

Key Documents

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Product Name

Bone Morphogenetic Protein 6 human, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

biological source

human

recombinant

expressed in NSO cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

0.05-0.15 μg/mL ED50

mol wt

30–38 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P22004

storage temp.

−20°C

Quality Level

100

Gene Information

human ... BMP6(654)

Analysis Note

The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells.

Biochem/physiol Actions

Cellular responses to BMP-6 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Mature human and murine BMP-6 demonstrates 96% homology.

Physical form

Lyophilized from 200 ul 0.2 μm filtered solution in 40% acetonitrile, 0.1% trifluoroacetic acid containing 50ug bovine serum albumin per 1 ug as a carrier protein.

wgk

WGK 3

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCJ6778
MKCH3656
MKCC3713
021M1503
090M1219

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Bone morphogenetic proteins and their receptors: potential functions in the brain.
Ebendal, T., et al
The Journal of Neuroscience, 51, 139-146 (1998)
Stephanie Arndt et al.
Gut, 64(6), 973-981 (2014-07-12)
Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis. However, its further role in liver pathology including non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH) is elusive. The aim of this
Christine E McLaren et al.
Hepatology (Baltimore, Md.), 62(2), 429-439 (2015-01-22)
To identify polymorphisms associated with variability of iron overload severity in HFE-associated hemochromatosis, we performed exome sequencing of DNA from 35 male HFE C282Y homozygotes with either markedly increased iron stores (n = 22; cases) or with normal or mildly increased iron
Hiroshi Kawabata et al.
Experimental hematology, 43(5), 404-413 (2015-01-31)
Hepcidin is the central regulator of systemic iron homeostasis; dysregulation of hepcidin expression causes various iron metabolic disorders, including hereditary hemochromatosis and anemia of inflammation. To identify molecules that modulate hepcidin expression, we developed a bioassay system for hepcidin gene
Zhu Xishan et al.
Journal of experimental & clinical cancer research : CR, 30, 47-47 (2011-05-04)
Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells within the leukemic population that possess extensive proliferation and self-renewal capacity not
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