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A5979

Sigma-Aldrich

Anti-ARP3 antibody, Mouse monoclonal

clone FMS338, purified from hybridoma cell culture

Synonym(s):

ARP3 Detection Antibody, Mouse Anti-ARP3

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100 μG
CN¥4,985.59

CN¥4,985.59

Estimated to ship onApril 15, 2025Details

A recombinant, preservative-free antibody is available for your target. Try ZMS1017
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100 μG
CN¥4,985.59

About This Item

MDL number:
MFCD04118400
UNSPSC Code:
12352203
NACRES:
NA.41

CN¥4,985.59

Estimated to ship onApril 15, 2025Details

A recombinant, preservative-free antibody is available for your target. Try ZMS1017
Request a Bulk Order

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

FMS338, monoclonal

form

buffered aqueous solution

mol wt

antigen 40-45 kDa

species reactivity

human, mouse, rat, canine

packaging

antibody small pack of 25 μL

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antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

ascites fluid

antibody form

purified antibody

biological source

mouse

biological source

mouse

biological source

mouse

biological source

rat

shipped in

ambient

shipped in

ambient

shipped in

wet ice

shipped in

wet ice

technique(s)

ChIP: suitable, dot blot: suitable, immunoprecipitation (IP): suitable, affinity binding assay: suitable, immunocytochemistry: suitable

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

ChIP: suitable (ChIP-seq), ELISA: suitable, immunocytochemistry: suitable, western blot: suitable

isotype

IgG2aκ

isotype

IgG1

isotype

IgG1

isotype

IgG2bκ

General description

Monoclonal Anti-ARP3 (mouse IgG2b isotype) is derived from the hybridoma FMS338 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with recombinant human ARP3. Arp3 is mapped to human chromosome 2q14.1.

Immunogen

recombinant human ARP3.

Application

Monoclonal Anti-ARP3 antibody produced in mouse has been used in:
  • enzyme linked immunosorbent assay (ELISA)
  • immunocytochemistry
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence
  • immunohistochemistry

Biochem/physiol Actions

The ARP2/3 complex consists of seven distinct proteins (Arp2 and Arp3, p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc) that modulate polymerization of cellular actin filaments. ARP3 regulates actin nucleation, and is involved in directing the movement of Listeria monocytogenes in infected host cells. Monoclonal Anti-ARP3 antibody binds to human, canine, rat, and mouse ARP3.
The actin-related protein-2/3 (ARP2/3) is part of Wiskott-Aldrich Syndrome protein (WASP) signaling in mediating polymerization state of actin filaments. It has been found that ARP2/3 complex and its activator spinocerebellar ataxia, autosomal recessive 2 (Scar2) are involved in Golgi polarization in NIH 3T3 cells. However in primary astrocytes, Golgi polarization involves neither actin cytoskeleton or Arp2/3 complex nor any WASP-family of proteins. In a different model, it was found that the ARP2/3 complex was necessary for neutrophil chemotaxis and phagocytosis. By genetic and loss of function studies, it was demonstrated that Scar2 is the major regulator of the ARP2/3 complex rather than the WASP family of proteins, the latter having more restricted roles in specific cellular events.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000370993
    0000339701
    0000329430
    0000370993
    0000329430

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    Nan Li et al.
    Spermatogenesis, 6(1), e1206353-e1206353 (2016-08-26)
    Throughout the epithelial cycle of spermatogenesis, actin microfilaments arranged as bundles near the Sertoli cell plasma membrane at the Sertoli cell-cell interface that constitute the blood-testis barrier (BTB) undergo extensive re-organization by converting between bundled and unbundled/branched configuration to give
    Arp2/3 and VASP are essential for fear memory formation in lateral amygdala
    Basu S, et al.
    eNeuro, 3, 1279-1291 (2016)
    Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis
    Singh S, et al.
    The Journal of biological chemistry, 278(38), 36410-36417 (2003)
    Genome-wide association study suggested the PTPRD polymorphisms were associated with weight gain effects of atypical antipsychotic medications
    Yu H, et al.
    Schizophrenia Bulletin, 42(3) (2015)
    Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins
    Xiao X, et al.
    Human Reproduction, 29(6), 1279-1291 (2014)
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