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A2169

Sigma-Aldrich

3′-Azido-3′-deoxythymidine

≥98% (HPLC), powder, reverse transcriptase inhibitor

Synonym(s):

AZT, Azidothymidine, ZDV, Zidovudine

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25 MG
CN¥1,152.88
100 MG
CN¥3,407.59
250 MG
CN¥5,028.97
1 G
CN¥14,468.10

CN¥1,152.88

Available to ship onApril 23, 2025Details

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25 MG
CN¥1,152.88
100 MG
CN¥3,407.59
250 MG
CN¥5,028.97
1 G
CN¥14,468.10

About This Item

Empirical Formula (Hill Notation):
C10H13N5O4
CAS Number:
30516-87-1
Molecular Weight:
267.24
Beilstein:
3595791
MDL number:
MFCD00006536
UNSPSC Code:
12352200
PubChem Substance ID:
24278143
NACRES:
NA.77

CN¥1,152.88

Available to ship onApril 23, 2025Details

Request a Bulk Order

Product Name

3′-Azido-3′-deoxythymidine, ≥98% (HPLC)

Quality Level

200

Assay

≥98% (HPLC)

form

powder

mp

113-115 °C (lit.)

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

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1 of 4

This Item
PHR1292D1413G7504
3′-Azido-3′-deoxythymidine ≥98% (HPLC)

A2169

3′-Azido-3′-deoxythymidine

Zidovudine Pharmaceutical Secondary Standard; Certified Reference Material

PHR1292

Zidovudine

2′,3′-Didehydro-3′-deoxythymidine ≥98% (TLC)

D1413

2′,3′-Didehydro-3′-deoxythymidine

Guanosine 3′,5′-cyclic monophosphate ≥98% (HPLC), powder

G7504

Guanosine 3′,5′-cyclic monophosphate

form

powder

form

-

form

powder

form

powder

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

H2O: 50 mg/mL

solubility

-

solubility

-

solubility

0.2 M NaHCO3: 50 mg/mL

mp

113-115 °C (lit.)

mp

113-115 °C (lit.)

mp

-

mp

-

Application

3′-Azido-3′-deoxythymidine has been used as the reverse transcriptase inhibitor to inhibit the viral genome integration[1] and as an antimicrobial agent to evaluate its anti-Salmonella activity.[2]

Biochem/physiol Actions

Azidothymidine (AZT), a thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1 virus. Azidothymidine has been shown to decrease CRISPR-mediated homology-directed repair (HDR) efficiency.
Reverse transcriptase inhibitor active against HIV-1 virus.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H341,H351

Hazard Classifications

Carc. 2 - Muta. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Certificates of Analysis (COA)

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    MKCW5948
    MKCS1355
    MKCR8766
    MKCQ4508

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    Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection.
    Cabral-Piccin, et al.
    EBioMedicine, 91, 104557-104557 (2023)
    Zahidul Khan et al.
    Neuro-oncology, 12(6), 549-558 (2010-02-16)
    The prognosis for malignant gliomas remains poor, and new treatments are urgently needed. Targeted suicide gene therapy exploits the enzymatic conversion of a prodrug, such as a nucleoside analog, into a cytotoxic compound. Although this therapeutic strategy has been considered
    In vitro activities of nucleoside analog antiviral agents against salmonellae.
    Sperber S J, et al.
    Antimicrobial Agents and Chemotherapy, 37(1), 106-110 (1993)
    Marla E Tharp et al.
    Nature communications, 11(1), 330-330 (2020-01-18)
    Female reproductive success critically depends on the size and quality of a finite ovarian reserve. Paradoxically, mammals eliminate up to 80% of the initial oocyte pool through the enigmatic process of fetal oocyte attrition (FOA). Here, we interrogate the striking
    Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells.
    Zhao, et al.
    Cell discovery, 9, 45-45 (2023)
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