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PHR1292

Supelco

Zidovudine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

3′-Azido-3′-deoxythymidine, AZT, Azidothymidine, ZDV, Zidovudine

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1 EA
CN¥10,654.94

CN¥10,654.94

Available to ship onApril 14, 2025Details

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About This Item

Empirical Formula (Hill Notation):
C10H13N5O4
CAS Number:
30516-87-1
Molecular Weight:
267.24
Beilstein:
3595791
MDL number:
MFCD00006536
UNSPSC Code:
41116107
PubChem Substance ID:
329823283
NACRES:
NA.24

CN¥10,654.94

Available to ship onApril 14, 2025Details

Request a Bulk Order

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 803
traceable to Ph. Eur. Z1900000
traceable to USP 1724500

API family

zidovudine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

113-115 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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This Item
582711U53827U50630U
Ascentis® Express C18, 2.7 μm HPLC Column 2.7 μm particle size, L × I.D. 15 cm × 4.6 mm

53829U

Ascentis® Express C18, 2.7 μm HPLC Column

Ascentis® Express C18, 2.7 μm HPLC Column 2.7 μm particle size, L × I.D. 5 cm × 1 mm

582711U

Ascentis® Express C18, 2.7 μm HPLC Column

Ascentis® Express C18, 2.7 μm HPLC Column 2.7 μm particle size, L × I.D. 10 cm × 4.6 mm

53827U

Ascentis® Express C18, 2.7 μm HPLC Column

Ascentis® Express C18, 2.7 μm HPLC Column particle size, std dev 2.7 μm, L × I.D. 10 cm × 1.5 mm

50630U

Ascentis® Express C18, 2.7 μm HPLC Column

particle size

2.7 μm

particle size

2.7 μm

particle size

2.7 μm

particle size

std dev 2.7 μm

matrix

Fused-Core particle platform, superficially porous particle

matrix

Fused-Core particle platform, superficially porous particle

matrix

Fused-Core particle platform, superficially porous particle

matrix

Fused-Core particle platform

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

separation technique

-

agency

suitable for USP L1

agency

suitable for USP L1

agency

suitable for USP L1

agency

suitable for USP L1

technique(s)

HPLC: suitable, UHPLC-MS: suitable, LC/MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

-

General description

Zidovudine (AZT) is a thymidine analog anti-HIV drug, known to decrease the mortality rate in patients affected with HIV.[1] The mode of action involves inhibiting the activity of viral reverse transcriptase and interrupting HIV replication.[2]

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Zidovudine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, tablets and drug dosage forms by chromatography[3][4][5] and spectrophotometric techniques.[6]

Biochem/physiol Actions

Reverse transcriptase inhibitor active against HIV-1 virus.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0303 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H341,H351

Hazard Classifications

Carc. 2 - Muta. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Reverse Phase High Performance Liquid Chromatographic Determination Of Zidovudine And Lamivudine In Tablet Dosage Form.
Palled MS, et al.
Indian Journal of Pharmaceutical Sciences, 67(1), 110-110 (2005)
Photoelectron spectra of important drug molecules: Zidovudine and Artemisinine
Novak I and Kovac B
The Journal of Organic Chemistry, 68(14), 5777-5779 (2003)
Spectrophotometric determination of Zidovudine in pharmaceuticals based on charge-transfer complexation involving N-bromosuccinimide, metol and sulphanilic acid as reagents
Basavaiah K, et al.
Journal of Chemistry, 4(2), 173-179 (2007)
Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex
de Miranda P, et al.
Clinical Pharmacology and Therapeutics, 46(5), 494-499 (1989)
Simultaneous determination of HIV-protease inhibitors lamivudine and zidovudine in pharmaceutical formulations by micellar electrokinetic chromatography
Sekar R and Azhaguvel S
Journal of Pharmaceutical and Biomedical Analysis, 39(3-4), 653-660 (2005)
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