86339
Sodium taurocholate hydrate
≥97.0% (TLC)
Synonym(s):
Taurocholic acid sodium salt
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About This Item
Empirical Formula (Hill Notation):
C26H44NNaO7S · xH2O
CAS Number:
Molecular Weight:
537.68 (anhydrous basis)
Beilstein:
3901620
EC Number:
MDL number:
UNSPSC Code:
12161902
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
biological source
ox bile
synthetic
Quality Level
description
anionic
Assay
≥97.0% (TLC)
form
powder
optical activity
[α]20/D +23±1°, c = 3% in H2O (dry matter)
mol wt
537.68 g/mol (anhydrous basis)
impurities
≤1% taurine
≤2% cholic acid
solubility
H2O: 50 mg/mL, clear
functional group
sulfonic acid
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Application
Sodium taurocholate hydrate was used as an emulsifier in in situ preparation of digestive enzymes.
Biochem/physiol Actions
Taurocholic acid is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and deoxycholic acid. These are reabsorbed by the liver via a carrier-mediated process and converted by liver enzymes to taurocholic acid.
Preparation Note
Sodium taurocholate hydrate yields a clear, colorless solution in water at 50 mg/ml.
Other Notes
For the solubilization of unconjugated bilirubin
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Effect of biliary drainage on individual reactions in the conversion of cholesterol to taurochlic acid. Bile acids and steroids 180.
H Danielsson et al.
European journal of biochemistry, 2(1), 44-49 (1967-07-01)
Extreme tolerance to environmental stress of sexual and parthenogenetic resting eggs of Eucypris virens (Crustacea, Ostracoda)
Vandekerkhove J et al
Freshwater Biology, 58, 237-247 (2013)
L R Schwarz et al.
European journal of biochemistry, 55(3), 617-623 (1975-07-15)
Binding and transport characteristics for uptake of taurocholic acid by isolated rat liver cells were studied. 1. An adsorption of taurocholate to the cell surface is terminated in less than 15 s. A Ks of 0.55 mM and a total
Andrea Martinez Aguirre et al.
PLoS pathogens, 17(10), e1010015-e1010015 (2021-10-20)
Clostridioides difficile infections occur upon ecological / metabolic disruptions to the normal colonic microbiota, commonly due to broad-spectrum antibiotic use. Metabolism of bile acids through a 7α-dehydroxylation pathway found in select members of the healthy microbiota is regarded to be
Caiming Xu et al.
Journal of cellular and molecular medicine, 25(4), 1851-1866 (2021-01-14)
Long non-coding RNAs (lncRNAs) contribute to disease pathogenesis and drug treatment effects. Both emodin and dexamethasone (DEX) have been used for treating severe acute pancreatitis-associated acute lung injury (SAP-ALI). However, lncRNA regulation networks related to SAP-ALI pathogenesis and drug treatment
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