Skip to Content

尊敬的客户：

目前国际形势复杂多变，关税政策尚不明朗，这可能对我们的产品价格产生一定影响。在此情况下，我们希望就订单事宜与您进行友好沟通。

基于当前的不确定性，如果您选择在此期间下单，我们将保留根据实际情况调整价格的权利。同时，我们也理解市场变化可能给您带来的困扰，因此如果在订单实际发货前因关税政策变动导致价格出现较大波动，默克将与您进行协商讨论并视情况对订单进行调整或取消。

Merck
CN
All Photos(1)

Key Documents

View All Documentation

55865

Sigma-Aldrich

Digoxigenin NHS-ester

≥80% (HPLC)

Synonym(s):

ε-(Digoxigenin-3-0-acetamido)caproic acid N-hydroxysuccinimide ester, DIG NHS

Sign Into View Organizational & Contract Pricing

Select a Size

150 UNITS
CN¥3,624.54

CN¥3,624.54

Available to ship onApril 27, 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
150 UNITS
CN¥3,624.54

About This Item

Empirical Formula (Hill Notation):
C35H50N2O10
CAS Number:
129273-26-3
Molecular Weight:
658.78
MDL number:
MFCD02093394
UNSPSC Code:
12352108
PubChem Substance ID:
57651557
NACRES:
NA.25

CN¥3,624.54

Available to ship onApril 27, 2025Details

Request a Bulk Order

Quality Level

200

Assay

≥80% (HPLC)

form

solid

shipped in

wet ice

storage temp.

−20°C

SMILES string

[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)C5=CC(=O)OC5)[C@@]1(C)CC[C@@H](C2)OCC(=O)NCCCCCC(=O)ON6C(=O)CCC6=O

InChI

1S/C35H50N2O10/c1-33-13-11-23(45-20-28(39)36-15-5-3-4-6-31(42)47-37-29(40)9-10-30(37)41)17-22(33)7-8-25-26(33)18-27(38)34(2)24(12-14-35(25,34)44)21-16-32(43)46-19-21/h16,22-27,38,44H,3-15,17-20H2,1-2H3,(H,36,39)/t22-,23+,24-,25-,26+,27-,33+,34+,35+/m1/s1

InChI key

KHNDABJZSPPYLE-FUGFVFQCSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
112077419101109327491011988506001
抗 荧光素-AP、Fab 片段 from sheep

11426338910

抗 荧光素-AP、Fab 片段

抗-地高辛-荧光素，Fab片段 from sheep

11207741910

抗-地高辛-荧光素，Fab片段

抗地高辛-AP，Fab片段 from sheep

11093274910

抗地高辛-AP，Fab片段

抗-HA-荧光素，高亲和力 from rat IgG1

11988506001

抗-HA-荧光素，高亲和力

antibody form

affinity purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

3F10, monoclonal

conjugate

alkaline phosphatase conjugate

conjugate

fluorescein conjugate

conjugate

alkaline phosphatase conjugate

conjugate

fluorescein conjugate

biological source

sheep

biological source

sheep

biological source

sheep

biological source

rat

form

solution

form

lyophilized

form

solution

form

lyophilized

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Application

Digoxigenin NHS-ester has been used in the preparation of streptavidin-digoxigenin conjugate and digoxin-recombinant Ara h1 (peanut component) conjugate for enzyme-linked immunosorbent assay (ELISA) analysis.

Biochem/physiol Actions

Digoxigenin NHS-ester is an activated ester that reacts with amino groups under mild conditions, attaching the digoxigenin moiety to proteins or 5′-amino substituted oligonucleotides[1][2] Digoxigenin labeling is used to immuno-tag molecules for detection using anti-digoxigenin antibodies with high affinities and specificity.
Digoxigenin, an aglycon, is a pharmacologically active plant toxin. It is less potent than digoxin. It is used in lower doses to treat heart conditions. Digoxigenin is usually conjugated to another payload which reduces its remaining activity or accessibility to tissues. Since digoxigenin is permanently bound and entirely covered by the capture modules, it cannot be used as an active entity.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H300 + H310 + H330,H373

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCM3603
    BCCM0721
    BCCM0773
    BCCJ7940
    BCCH9725

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Isotype-specific agglutination-PCR (ISAP): A sensitive and multiplex method for measuring allergen-specific IgE.
    Cheng-Ting Tsai et al.
    The Journal of allergy and clinical immunology, 141(5), 1901-1904 (2017-12-19)
    R Antolovic et al.
    European journal of biochemistry, 227(1-2), 61-67 (1995-01-15)
    Na+/K(+)-ATPase from pig kidney is inactivated by protein-reactive N-hydroxysuccinimidyl derivatives of digoxigenin. Like digoxigenin, its protein-reactive derivatives N-hydroxysuccinimidyl digoxigenin-3-methylcarbonyl-epsilon-aminocaproate (HDMA), 3-amino-3-deoxydigoxigenin hemisuccinimide succinimidyl ester (ADHS), 3-iodoacetylamino-3-deoxydigoxigenin (IAD) and digoxigenin-3-O-succinyl-[2-(N-maleimido)]ethylamide (DSME) inhibited the sodium pump in the presence of Na+, Mg2+
    Demonstration of a specific transport protein for cardiac glycosides in bovine blood.
    R Antolovic et al.
    Annals of the New York Academy of Sciences, 834, 618-620 (1997-12-24)
    R Antolovic et al.
    FEBS letters, 368(1), 169-172 (1995-07-10)
    The digoxigenin derivative N-hydroxysuccinimidyl digoxigenin-3-O-methylcarbonyl-epsilon-aminocaproate (HDMA) has been shown to covalently label the ouabain binding site of the Na,K-ATPase epsilon subunit [Antolovic et al. (1995) Eur. J. Biochem. 227, 61-67]. In the present study we observed both, labeling and inactivation
    Silke Metz et al.
    Proceedings of the National Academy of Sciences of the United States of America, 108(20), 8194-8199 (2011-05-04)
    Bispecific antibodies that bind cell-surface targets as well as digoxigenin (Dig) were generated for targeted payload delivery. Targeting moieties are IgGs that bind the tumor antigens Her2, IGF1R, CD22, or LeY. A Dig-binding single-chain Fv was attached in disulfide-stabilized form
    View All Related Papers

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service