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3′-Deoxythymidine 5′-triphosphate sodium salt solution

BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)

Synonym(s):

2′,3′-Dideoxythymidine 5′-triphosphate, ddTTP

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About This Item

Empirical Formula (Hill Notation):
C10H16N2NaO13P3
CAS Number:
Molecular Weight:
488.15
MDL number:
UNSPSC Code:
41116105
PubChem Substance ID:

product line

BioChemika

grade

puriss. p.a.

Assay

≥98.0% (HPLC)

concentration

10.0-11.0 mmol/L (UV)

technique(s)

MALDI-MS: suitable

impurities

≤1.5% ddNDP (HPLC)

suitability

corresponds for UV test

storage temp.

−20°C

SMILES string

[Na+].CC1=CN([C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O

InChI

1S/C10H17N2O13P3.Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);/q;+1/p-1/t7-,8+;/m0./s1

InChI key

QJSZKDPCBDXBCK-KZYPOYLOSA-M

General description

3′-Deoxythymidine 5′-triphosphate sodium (ddTTP) is a sugar-modified dTTP analogue which is selective inhibitor of HIV-associated reverse transcriptase (HIV-RT). It is also seen to inhibit the activity of DNA polymerase α.

Packaging

packaging : 1 μmol (approx. 91-100 μL)

related product

Product No.
Description
Pricing

replaced by

Product No.
Description
Pricing

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kevin A Fiala et al.
Nucleic acids research, 36(6), 1990-2001 (2008-02-16)
Our previous publication shows that Sulfolobus solfataricus Dpo4 utilizes an 'induced-fit' mechanism to select correct incoming nucleotides at 37 degrees C. Here, we provide a comprehensive report elucidating the kinetic mechanism of a DNA polymerase at a reaction temperature higher
Inhibition of the activity of DNA polymerase alpha by 2',3'-dideoxythymidine 5'-triphosphate.
K Ono et al.
Biochemical and biophysical research communications, 88(4), 1255-1262 (1979-06-27)
Sascha Tierling et al.
Epigenetics & chromatin, 3(1), 12-12 (2010-06-08)
DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or complex tissue samples is crucial for the understanding of tumor etiology
Sylvia Steininger et al.
Nucleic acids research, 38(6), 1853-1865 (2009-12-31)
The Mre11/Rad50/Xrs2 (MRX) complex in Saccharomyces cerevisiae has well-characterized functions in DNA double-strand break processing, checkpoint activation, telomere length maintenance and meiosis. In this study, we demonstrate an involvement of the complex in the base excision repair (BER) pathway. We
Elena N Ilina et al.
Frontiers in microbiology, 4, 186-186 (2013-07-13)
Spectinomycin remains a useful reserve option for therapy of gonorrhea. The emergence of multidrug-resistant Neisseria gonorrhoeae strains with decreased susceptibility to cefixime and to ceftriaxone makes it the only medicine still effective for treatment of gonorrhea infection in analogous cases.

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