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Merck
CN

42597

3′-Deoxythymidine 5′-triphosphate sodium salt solution

BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)

Synonym(s):

2′,3′-Dideoxythymidine 5′-triphosphate, ddTTP

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About This Item

Empirical Formula (Hill Notation):
C10H16N2NaO13P3
CAS Number:
128524-26-5
Molecular Weight:
488.15
UNSPSC Code:
41116105
PubChem Substance ID:
329756245
MDL number:
MFCD00079155

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Product Name

3′-Deoxythymidine 5′-triphosphate sodium salt solution, BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)

InChI

1S/C10H17N2O13P3.Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);/q;+1/p-1/t7-,8+;/m0./s1

SMILES string

[Na+].CC1=CN([C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O

InChI key

QJSZKDPCBDXBCK-KZYPOYLOSA-M

product line

BioChemika

grade

puriss. p.a.

assay

≥98.0% (HPLC)

concentration

10.0-11.0 mmol/L (UV)

technique(s)

MALDI-MS: suitable

impurities

≤1.5% ddNDP (HPLC)

suitability

corresponds for UV test

storage temp.

−20°C

General description

3′-Deoxythymidine 5′-triphosphate sodium (ddTTP) is a sugar-modified dTTP analogue which is selective inhibitor of HIV-associated reverse transcriptase (HIV-RT). It is also seen to inhibit the activity of DNA polymerase α.

Packaging

packaging : 1 μmol (approx. 91-100 μL)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBN4637V
BCBK6773V
BCBG8138V
BCBF6603

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Spectinomycin remains a useful reserve option for therapy of gonorrhea. The emergence of multidrug-resistant Neisseria gonorrhoeae strains with decreased susceptibility to cefixime and to ceftriaxone makes it the only medicine still effective for treatment of gonorrhea infection in analogous cases.
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Nucleic acids research, 38(6), 1853-1865 (2009-12-31)
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The beneficial effects of moderate red wine consumption on cardiovascular health are well known. The composition of red wine includes several compounds, such as the phytoestrogen resveratrol, that exert these beneficial effects, although not all the mechanisms by which they
Inhibition of the activity of DNA polymerase alpha by 2',3'-dideoxythymidine 5'-triphosphate.
K Ono et al.
Biochemical and biophysical research communications, 88(4), 1255-1262 (1979-06-27)
Sascha Tierling et al.
Epigenetics & chromatin, 3(1), 12-12 (2010-06-08)
DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or complex tissue samples is crucial for the understanding of tumor etiology
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