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400M-1

Sigma-Aldrich

ALDH1A1 (44) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

44, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (400M-14)
vial of 0.5 mL concentrate (400M-15)
bottle of 1.0 mL predilute (400M-17)
vial of 1.0 mL concentrate (400M-16)
bottle of 7.0 mL predilute (400M-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG1

control

solitary fibrous tumor

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... ALDH1A1(216)

General description

ALDH1A1 belongs to the ALDH enzymes, a family of evolutionarily conserved enzymes comprised of 19 isoforms that are localized in the cytoplasm, mitochondria or nucleus. ALDH1A1 is predominantly expressed in the epithelium of testis, brain, eye, liver, kidney, as well as neural and hematopoietic stem cells. Recently, it has been reported that high ALDH1A1 mRNA expression was seen in solitary fibrous tumor (SFT) and hemangiopericytoma (HPC), compared to meningiomas and synovial sarcomas. An immunohistochemical study with ALDH1 A1 antibody in 243 meningeal tumors (tissue microarray), including 25 central nervous system SFTs, 13 extrameningeal SFTs, 55 central nervous system HPCs, 163 meningiomas, and 98 synovial sarcomas found that 21 of 25 meningeal SFTs (84%), 11 of 13 extrameningeal SFTs (84.6%), and 18 of 24 (85.4%) meningeal HPCs were positive with anti-ALDH1A1 antibody. Anti-ALDH1A1 can be combined with anti-CD34 to aid in the differentiation between SFT, HPC, meningioma, and synovial sarcoma. 24/25 (96%) meningeal SFTs and 54/55 (98%) meningeal HPCs were positive for ALDH1A1 and/or CD34 whereas only 10/163 (6%) meningiomas and 7/98 (7%) synovial sarcomas were positive for ALDH1A1 and/or CD34. Anti-ALDH1A1 IHC has been recommended for routine use in association with anti-CD34 for the differentiation among SFT, HPC, meningioma, and synovial sarcoma.

Quality


IVD
IVD
IVD
RUO

Linkage

ALDH1A1 Positive Control Slides, Product No. 400S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000105303
0000101621
0000090934
0000082065
0000082064

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Paola Marcato et al.
Cell cycle (Georgetown, Tex.), 10(9), 1378-1384 (2011-05-10)
Recent evidence suggests that enhanced aldehyde dehydrogenase (ALDH) activity is a hallmark of cancer stem cells (CSC) measurable by the aldefluor assay. ALDH1A1, one of 19 ALDH isoforms expressed in humans, was generally believed to be responsible for the ALDH
Corinne Bouvier et al.
Acta neuropathologica communications, 1, 10-10 (2013-11-21)
Solitary Fibrous Tumours (SFT) and haemangiopericytomas (HPC) are rare meningeal tumours that have to be distinguished from meningiomas and more rarely from synovial sarcomas. We recently found that ALDH1A1 was overexpressed in SFT and HPC as compared to soft tissue
John P Chute et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(31), 11707-11712 (2006-07-22)
Aldehyde dehydrogenase (ALDH) is an enzyme that is expressed in the liver and is required for the conversion of retinol (vitamin A) to retinoic acids. ALDH is also highly enriched in hematopoietic stem cells (HSCs) and is considered a selectable

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