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33427

Supelco

2,4-TDI

analytical standard

Synonym(s):

Toluene 2,4-diisocyanate, 2,4-Diisocyanatotoluene, 4-Methyl-m-phenylene diisocyanate, Tolylene 2,4-diisocyanate

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About This Item

Empirical Formula (Hill Notation):
C9H6N2O2
CAS Number:
584-84-9
Molecular Weight:
174.16
Beilstein:
744602
EC Number:
209-544-5
MDL number:
MFCD00002011
UNSPSC Code:
41116107
PubChem Substance ID:
329754539
NACRES:
NA.24

grade

analytical standard

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

124-126 °C/18 mmHg (lit.)
251 °C (lit.)

mp

19.5-21.5 °C (lit.)

density

1.22 g/mL at 20 °C (lit.)

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

storage temp.

room temp

SMILES string

Cc1ccc(cc1N=C=O)N=C=O

InChI

1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3

InChI key

DVKJHBMWWAPEIU-UHFFFAOYSA-N

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General description

2,4-TDI is an environmental contaminant belonging to the class of diisocyanates. It is commercially used as a starting material for varnishes, paints, elastomers, polyurethane foams, wire enamels, etc.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food.

Find all available reference materials for compounds listed in 10/2011 here

Application

2,4-TDI may be used as an analytical reference standard for the quantification of the analyte in gas-phase and biological fluids using chromatography techniques.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 2

Flash Point(F)

269.6 °F

Flash Point(C)

132 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of gas-phase produced ethyl parathion and toluene 2, 4-diisocyanate by ion mobility spectrometry, gas chromatography and liquid chromatography
Nousiainen M, et al.
Talanta, 72(3), 984-990 (2007)
Biological monitoring of occupational exposure to toluene diisocyanate: measurement of toluenediamine in hydrolysed urine and plasma by gas chromatography-mass spectrometry
Persson P, et al.
Occupational and Environmental Medicine, 50(12), 1111-1118 (1993)
Norman Mangner et al.
JACC. Cardiovascular imaging, 7(12), 1198-1205 (2014-10-13)
The aim of our study was to assess geometric and functional changes of the heart in obese compared with nonobese children and adolescents. Obesity in children and adolescents has increased over the past decades and is considered a strong risk
Tatiana Kuznetsova et al.
American journal of hypertension, 28(4), 535-545 (2014-09-23)
The cardio-renal interaction occurs via hemodynamic and humoral factors. Noninvasive assessment of renal hemodynamics is currently possible by assessment of renal resistive index (RRI) derived from intrarenal Doppler arterial waveforms as ((peak systolic velocity - end-diastolic velocity)/peak systolic velocity). Limited
Gabriele Sabbioni et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 17(2), 150-159 (2012-01-11)
Toluene diisocyanates (2,4-TDI and 2,6-TDI) are important intermediates in the chemical industry. Among the main damages after low levels of TDI exposure are lung sensitization and asthma. It is therefore necessary to have sensitive and specific methods to monitor isocyanate
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