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24368C

SAFC

EX-CELL® Advanced CHO Feed 1 (without glucose)

Pharma Manufacturing

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Synonym(s):
EX-CELL® Advanced CHO Feed 1
UNSPSC Code:
12352200
NACRES:
NA.71

product line

EX-CELL®

Quality Level

500

form

dry powder

technique(s)

cell culture | mammalian: suitable (suspension)

shipped in

ambient

storage temp.

2-8°C

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General description

EX-CELL® Advanced CHO Feed 1 (without glucose) is chemically-defined and contains no animal derived components. This feed is intended to be a part of a fed-batch platform, and used with EX-CELL® Advanced CHO Fed-batch Medium (14366C or 24366C). This newest platform from SAFC has been specifically developed to support growth and productivity across a diverse set of Chinese Hamster Ovary (CHO) cells in fed-batch cultures while still allowing for flexibility in the adjustment of protein quality attributes. This contemporary fed-batch platform was developed using a strategy of Multivariate Analysis to establish correlations in which the formulation components influence critical process and product attributes such as titer, fold expansion, receptor expression, and glycosylation. This platform contains no hypoxanthine and thymidine, L-glutamine, phenol red or 2-mercaptoethanol (2-ME).

Linkage

Submit the EX-CELL Advanced CHO Fed-batch request form to get in touch with a SAFC representative.

Quantity

Formulated to contain 64.1 grams of powder per liter of medium.

Legal Information

EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H315,H317,H318

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

WGK

WGK 3

Regulatory Information

动植物来源培养基

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Pao-Chun Lin et al.
mAbs, 11(5), 965-976 (2019-05-03)
Chinese hamster ovary (CHO) cells are the biopharmaceutical industry's primary means of manufacturing therapeutic proteins, including monoclonal antibodies. The major challenge in cell line development for the production of recombinant biopharmaceuticals lies in generating and isolating rare high-producing stable clones

Articles

One-step Feed Optimization for Upstream Cell Culture Processes

Optimizing feed for upstream cell culture improves monoclonal antibody production, but requires balancing outcomes for both viable cell density and productivity.

EX-CELL® Advanced™ CHO Fed-Batch System – Bioprocessing Technology Institute, Singapore Case Study

In this study, nine commercially available, chemically defined media and feed combinations from different vendors were assessed for producing monoclonal antibody in Chinese hamster ovary (CHO) cells.

Improving Fed-batch Yields in Upstream Bioprocessing

Our step-by-step guide to optimizing media and feed combinations for upstream bioprocessing.

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