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21882

Sigma-Aldrich

5(6)-Carboxy-2′,7′-dichlorofluorescein

BioReagent, suitable for fluorescence, ≥95% (TLC)

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400 μL
CN¥1,636.44

CN¥1,636.44

Available to ship onApril 17, 2025Details

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400 μL
CN¥1,636.44

About This Item

Empirical Formula (Hill Notation):
C21H10Cl2O7
CAS Number:
111843-78-8
Molecular Weight:
445.21
MDL number:
MFCD00037452
UNSPSC Code:
12352108
PubChem Substance ID:
57647948
NACRES:
NA.32

CN¥1,636.44

Available to ship onApril 17, 2025Details

Request a Bulk Order

product line

BioReagent

Assay

≥95% (TLC)

form

solid

pKa 

5.1

mp

≥250 °C (lit.)

solubility

DMF: soluble
DMSO: soluble
H2O: soluble (pH ≥ 5)

fluorescence

λex 504 nm; λem 529 nm in 0.1 M Tris pH 8.0

suitability

suitable for fluorescence

SMILES string

OC(=O)c1ccc(c(c1)C(O)=O)C2=C3C=C(Cl)C(=O)C=C3Oc4cc(O)c(Cl)cc24.OC(=O)c5ccc(C(O)=O)c(c5)C6=C7C=C(Cl)C(=O)C=C7Oc8cc(O)c(Cl)cc68

InChI

1S/2C21H10Cl2O7/c22-13-4-11-17(6-15(13)24)30-18-7-16(25)14(23)5-12(18)19(11)10-3-8(20(26)27)1-2-9(10)21(28)29;22-13-4-11-17(6-15(13)24)30-18-7-16(25)14(23)5-12(18)19(11)9-2-1-8(20(26)27)3-10(9)21(28)29/h2*1-7,24H,(H,26,27)(H,28,29)

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This Item
110514820011114095700111051458001
ATP Lithium salt

11140965001

ATP

dTTP Lithium salt

11051482001

dTTP

GTP =98% (HPLC), solution, pkg of 400 μL (100 mM; 40 μmol)

11140957001

GTP

dCTP =98%, solution, 100 mM, suitable for DNA sequencing, suitable for DNA amplification

11051458001

dCTP

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

assay

97% (HPLC)

assay

≥98%

assay

98% (HPLC)

assay

98%

form

solution

form

solution

form

solution

form

solution

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

concentration

100 mM

concentration

100 mM

concentration

-

concentration

100 mM

Application

5(6)-Carboxy-2′,7′-dichlorofluorescein may be used as a specific substrate/probe to study the identity, activity and specificity of multidrug resistance protein 2 (MRP2) molecules.
suitable as pH-indicator

Other Notes

Fluorescent intracellular pH indicator in the pH 4-5 range[1]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Jannik Vindeløv et al.
    Yeast (Chichester, England), 19(5), 429-439 (2002-03-29)
    The effect of hyperosmotic shock on cell volume, vacuole volume, and intracellular pH (pH(i)) of individual cells of Saccharomyces cerevisiae and Zygosaccharomyces mellis was investigated. After transfer from a high water activity (a(w)) medium to low a(w) media, the growth
    Christian Lechner et al.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 75(2), 284-290 (2010-03-24)
    To establish a fluorescence-based assay for drug interactions with the ABC-export-protein MRP2 (ABCC2). Apical membrane vesicles were isolated by differential centrifugation from polarized MDCKII cells and MDCKII cells transfected with human MRP2. Vesicle fractions were characterized by electron microscopy, determination
    Amélie Moreau et al.
    Fundamental & clinical pharmacology, 25(6), 743-752 (2011-01-08)
    Macrophages represent major cellular targets of various drugs, especially antibiotics and anti-viral drugs. Factors that may govern intracellular accumulation of drugs in these cells, especially those related to activity of drug transporters, are consequently likely important to consider. The present
    Kati-Sisko Vellonen et al.
    Journal of pharmaceutical sciences, 99(2), 1087-1098 (2009-07-23)
    ATP-binding cassette (ABC) transporters are able to efflux their substrate drugs from the cells. We compared expression of efflux proteins in normal human corneal epithelial tissue, primary human corneal epithelial cells (HCEpiC), and corneal epithelial cell culture model (HCE model)
    L Payen et al.
    Biochemical pharmacology, 60(12), 1967-1975 (2000-12-08)
    Organic anion secretion by human hepatocytes was characterized using primary liver parenchymal cell cultures and the anionic fluorescent dye carboxy-2',7'-dichlorofluorescein (CF). Probenecid, a well-known common blocker of the membrane transport process for anions, was shown to increase CF accumulation in
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