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04076

Sigma-Aldrich

6-(p-Toluidino)-2-naphthalenesulfonyl chloride

suitable for fluorescence, ≥98.0% (HPLC)

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Synonym(s):
2,6-TNS-Cl, 6-(4-Methylanilino)naphthalene-2-sulfonylchloride, 6-[(4-methylphenyl)amino]-2-naphthalenesulfonylchloride
Empirical Formula (Hill Notation):
C17H14ClNO2S
CAS Number:
62778-24-9
Molecular Weight:
331.82
Beilstein:
6521872
MDL number:
MFCD00037749
UNSPSC Code:
12352200
PubChem Substance ID:
329747873
NACRES:
NA.32

Quality Level

100

Assay

≥98.0% (HPLC)

solubility

DMF: soluble
acetonitrile: soluble

fluorescence

λex 381 nm in methanol

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

Cc1ccc(Nc2ccc3cc(ccc3c2)S(Cl)(=O)=O)cc1

InChI

1S/C17H14ClNO2S/c1-12-2-6-15(7-3-12)19-16-8-4-14-11-17(22(18,20)21)9-5-13(14)10-16/h2-11,19H,1H3

InChI key

NONZPGMJWHNDKP-UHFFFAOYSA-N

Application

6-(p-Toluidino)-2-naphthalenesulfonyl chloride is a fluorescent, hydrophobic probe utilized for labeling peptides to monitor conformational changes of a molecular assembly by measuring alterations in fluorescence intensity .

Analysis Note

Emmax: none
do not dissolve in DMSO

Other Notes

Probe for determining the polarity in biological matrices

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J.R. Lakowicz
Principles of Fluorescence Spectroscopy (1983)

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