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494496

Sigma-Aldrich

NMP

biotech. grade, ≥99.7%

Synonym(s):

1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP

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Estimated to ship onApril 11, 2025Details

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About This Item

Empirical Formula (Hill Notation):
C5H9NO
CAS Number:
872-50-4
Molecular Weight:
99.13
Beilstein:
106420
EC Number:
212-828-1
MDL number:
MFCD00003193
UNSPSC Code:
12352005
PubChem Substance ID:
329757456
NACRES:
NA.07
grade:
biotech. grade
application(s):
peptide synthesis
bp:
202 °C (lit.)
81-82 °C/10 mmHg (lit.)
vapor pressure:
0.29 mmHg ( 20 °C)
0.99 mmHg ( 40 °C)

CN¥1,323.20

Estimated to ship onApril 11, 2025Details

Request a Bulk Order

Product Name

1-Methyl-2-pyrrolidinone, biotech. grade, ≥99.7%

grade

biotech. grade

Quality Level

100

vapor density

3.4 (vs air)

vapor pressure

0.29 mmHg ( 20 °C)
0.99 mmHg ( 40 °C)

Assay

≥99.7%

form

liquid

autoignition temp.

518 °F

expl. lim.

9.5 %

impurities

≤0.005% water
≤0.01% free amines (CH3NH2)

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General description

N-Methyl-2-pyrrolidinone (N-methylpyrrolidone, NMP) is a polar cyclic organic solvent.[1] A study on the impact of NMP on Saccharomyces cerevisiae revealed that it induced aneuploidy.[2] Characteristic properties of NMP include low viscosity, excellent dissolving power and enhanced demulsifying property. It is a better alternative to phenol in selectively treating lube feedstock.[3] The behavior of fullerene-C60 in NMP solution has been examined based on electronic absorption and photoluminescence spectral data.[1] A solution of sodium borohydride (NaBH4) in NMP showed increased reactivity towards debromination of alkyl bromide.[4] The enhanced selectivity of NMP-ethylene glycol solvent mixture for aromatic hydrocarbon extraction has been analyzed by gas chromatography.[5]

Packaging

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Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H335,H360D

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

195.8 °F - Pensky-Martens closed cup

Flash Point(C)

91 °C - Pensky-Martens closed cup

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SHBS4184
    SHBR5512
    SHBR5993
    SHBR7441
    SHBS0603

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    Evaluation of extraction properties of N-methylpyrrolidone and ethylene glycol mixtures by gas chromatography.
    Wardencki W and Tameesh AHH.
    Journal of Chemical Technology and Biotechnology, 31(1), 86-92 (1981)
    NaBH4 in N-methylpyrrolidone: a safe alternative for hydride displacement reaction.
    Torisawa Y, et al.
    Bioorganic & Medicinal Chemistry Letters, 11(20), 2787-2789 (2001)
    Sanjairaj Vijayavenkataraman et al.
    Artificial organs, 43(5), 515-523 (2018-09-20)
    The incidence of peripheral nerve injuries is on the rise and the current gold standard for treatment of such injuries is nerve autografting. Given the severe limitations of nerve autografts which include donor site morbidity and limited supply, neural guide
    N-methylpyrrolidone instead of phenol in treatment of lube feedstock.
    Ivanov AV, et al.
    Chemistry and Technology of Fuels and Oils, 36(5), 352-354 (2000)
    Aggregation of fullerene C60 in N-methylpyrrolidone.
    Yevlampieva NP, et al.
    Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 209(2), 167-171 (2002)
    View All Related Papers

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