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Y0001094

Aceclofenac for peak identification

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
Aceclofenac, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;
Empirical Formula (Hill Notation):
C16H13Cl2NO4
CAS Number:
89796-99-6
Molecular Weight:
354.18
MDL number:
MFCD00864296
UNSPSC Code:
41116107
PubChem Substance ID:
329831261
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

aceclofenac

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)

InChI key

MNIPYSSQXLZQLJ-UHFFFAOYSA-N

Gene Information

human ... PTGS2(5743)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aceclofenac for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H319,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S S Kulthe et al.
Colloids and surfaces. B, Biointerfaces, 88(2), 691-696 (2011-08-25)
Pluronic block copolymers offer affluent phase behavioral characteristics and are extensively investigated for drug delivery applications. Hydrophobic Pluronics produce larger aggregates whereas hydrophilic Pluronics often generate small-sized micelles in aqueous milieu. To overcome the limitations and combine the advantages of
R Andrew Moore et al.
The Cochrane database of systematic reviews, (3)(3), CD007588-CD007588 (2009-07-10)
Aceclofenac is the prodrug of the non-steroidal anti-inflammatory drug (NSAID) diclofenac, widely used to treat acute and chronic pain. There are no known systematic reviews of its analgesic efficacy in acute postoperative pain. This review sought to evaluate the efficacy
Madhusmruti Khandai et al.
Current drug delivery, 9(5), 495-505 (2012-04-24)
The aim of this present research work was to prepare and evaluate alginate microspheres of aceclofenac by ionic gelation method for targeting the drug release in intestinal region and decrease distinct tissue protection in the stomach. This method offers to
Jhi-Kai Chang et al.
Clinical rheumatology, 32(3), 341-347 (2012-11-30)
This study aimed to determine the safety and efficacy of tramadol 37.5 mg/acetaminophen 325 mg combination tablets (Ultracet®) in patients with ankylosing spondylitis (AS). This was a 12-week, randomized, double-blind, placebo-controlled study. Sixty patients with active AS according to the
K Karthikeyan et al.
AAPS PharmSciTech, 13(1), 143-149 (2011-12-15)
Nonsteroidal anti-inflammatory drugs (NSAIDs) induce gastric injury on long-term usage. This study aims at reducing the side effect of NSAIDs by encapsulating in zein, an acid-resistant biopolymer. Aceclofenac-loaded zein microspheres were prepared by emulsification and solvent evaporation method. The stability
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