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Y0000218

Ondansetron hydrochloride dihydrate

Name: Ondansetron hydrochloride dihydrate
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride, GR 38032F

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₉N₃O · HCl · 2H₂O

CAS Number:

103639-04-9

Molecular Weight:

365.85

MDL number:

MFCD00374371

UNSPSC Code:

41116107

PubChem Substance ID:

329830885

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

ondansetron

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C

InChI

1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2

InChI key

VRSLTNZJOUZKLX-UHFFFAOYSA-N

Gene Information

human ... HTR3A(3359)

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Related Categories

Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ondansetron hydrochloride dihydrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

5-HT₃serotonin receptor antagonist

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1478618

1478593

1478629

PHR2224

PHR2223

PHR2221

Pictograms

GHS06,GHS05,GHS09

Signal Word

Danger

Hazard Statements

H301,H318,H410

Precautionary Statements

P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P391

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Thiolated xyloglucan: Synthesis, characterization and evaluation as mucoadhesive in situ gelling agent.

Hitendra S Mahajan et al.

Carbohydrate polymers, 91(2), 618-625 (2012-11-06)

The objective of present study was to enhance bioadhesive potential of xyloglucan by thiolation. Thiolation of xyloglucan was achieved with esterification with thioglycolic acid. Thiolated xyloglucan was characterized by NMR, DSC, and XRD analysis. Thiolated xyloglucan was determined to possess

Clinical and economic impact of oral ondansetron for vomiting in a pediatric emergency department.

Daniel Hervás et al.

Pediatric emergency care, 28(11), 1166-1168 (2012-11-02)

In this study, we determine the clinical impact of 1 dose of oral ondansetron for children with vomiting and evaluate the economic consequences of its use. The strategies compared were administering oral ondansetron in addition to oral rehydration therapy (group

A pilot study of full-dose ondansetron to treat heavy-drinking men withdrawing from alcohol in Brazil.

João Maria Corrêa Filho et al.

Addictive behaviors, 38(4), 2044-2051 (2013-02-12)

Ondansetron has emerged as a promising medication for the treatment of alcohol dependence, mainly among early-onset alcoholics. This research primarily aimed to evaluate the efficacy and safety of ondansetron at a 16mg/day dosage to treat alcohol-dependent outpatients. A double-blind, placebo-controlled

Development of HPTLC method for the estimation of ondansetron hydrochloride in bulk drug and sublingual tablets.

Ali Mujtaba et al.

Drug testing and analysis, 5(2), 122-125 (2013-02-16)

A new, simple, rapid, accurate and precise high performance thin layer chromatography (HPTLC) method has been developed for the estimation of ondansetron hydrochloride in bulk and sublingual tablets. The mobile phase composition was chloroform : ethyl acetate : methanol :

Prophylactic ondansetron does not prevent shivering or decrease shivering severity during cesarean delivery under combined spinal epidural anesthesia: a randomized trial.

Roger M Browning et al.

Regional anesthesia and pain medicine, 38(1), 39-43 (2012-10-30)

Cesarean delivery is commonly performed under regional anesthesia, which is often associated with maternal shivering. This can cause distress and interfere with monitoring. The study objective was to evaluate the antishivering efficacy of ondansetron, which reduces the incidence and severity

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