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T2550000

Tris Base

Name: Tris Base
Brand: SIAL

solid, pharmaceutical primary standard, European Pharmacopoeia (EP) Reference standard

Synonym(s):

Tromethamine, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Tris(hydroxymethyl)aminomethane, Trometamol, Tris

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About This Item

Empirical Formula (Hill Notation):

C₄H₁₁NO₃

CAS Number:

77-86-1

Molecular Weight:

121.14

EC Number:

201-064-4

MDL number:

MFCD00004679

UNSPSC Code:

41116107

PubChem Substance ID:

329826713

NACRES:

NA.24

product name

Trometamol, European Pharmacopoeia (EP) Reference Standard

grade

pharmaceutical primary standard

API family

trometamol, tromethamine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

Tris

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for use in the identification of trometamol using Infra-red absorption spectroscopy and preparation of reference solution (a) to test related substances in trometamol using thin-layer chromatography (General text 2.2.27), as per monograph 1053 of European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Trometamol

European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare

European pharmacopoeia, 4107-4108 (2017)

Acquisition strategy to reduce cerebrospinal fluid partial volume effects for improved DTI tractography.

Corey A Baron et al.

Magnetic resonance in medicine, 73(3), 1075-1084 (2014-04-12)

An acquisition method that does not increase scan time or specific absorption rate is investigated for reducing the deleterious effects of cerebrospinal fluid (CSF) partial volume effects on diffusion tensor imaging (DTI) tractography. It is based on using a shorter

Magnetic nanoparticles to recover cellular organelles and study the time resolved nanoparticle-cell interactome throughout uptake.

Filippo Bertoli et al.

Small (Weinheim an der Bergstrasse, Germany), 10(16), 3307-3315 (2014-04-17)

Nanoparticles in contact with cells and living organisms generate quite novel interactions at the interface between the nanoparticle surface and the surrounding biological environment. However, a detailed time resolved molecular level description of the evolving interactions as nanoparticles are internalized

Clinical pharmacokinetics of ketorolac tromethamine.

D R Brocks et al.

Clinical pharmacokinetics, 23(6), 415-427 (1992-12-01)

Ketorolac is a new chiral nonsteroidal anti-inflammatory drug (NSAID) which is marketed for analgesia as the racemate. The drug is administered as the water soluble tromethamine salt and is available in tablets or as an intramuscular injection. The absorption of

Water-soluble DNA minor groove binders as potential chemotherapeutic agents: synthesis, characterization, DNA binding and cleavage, antioxidation, cytotoxicity and HSA interactions.

Xia-Bing Fu et al.

Dalton transactions (Cambridge, England : 2003), 43(23), 8721-8737 (2014-04-29)

Two new water-soluble copper(ii)-dipeptide complexes: [Cu(glygly)(PyTA)]ClO4·1.5H2O (1) and [Cu(glygly)(PzTA)]ClO4·1.5H2O (2) (glygly = glycylglycine anion, PyTA = 2,4-diamino-6-(2'-pyridyl)-1,3,5-triazine and PzTA = 2,4-diamino-6-(2'-pyrazino)-1,3,5-triazine), utilizing two interrelated DNA base-like ligands (PyTA and PzTA), have been synthesized and characterized. The structure elucidation for 1

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