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PHR1380

Supelco

Ivermectin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Ivermectin, 22,23-Dihydroavermectin B1, MK-933

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1 G
CN¥1,584.20

CN¥1,584.20

Available to ship onApril 24, 2025Details

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1 G
CN¥1,584.20

About This Item

CAS Number:
70288-86-7
EC Number:
274-536-0
MDL number:
MFCD00869511
UNSPSC Code:
41116107
PubChem Substance ID:
329823357
NACRES:
NA.24

CN¥1,584.20

Available to ship onApril 24, 2025Details

Request a Bulk Order

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 864
traceable to Ph. Eur. I8000010
traceable to USP 1354309

API family

ivermectin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC

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Ivermectin Pharmaceutical Secondary Standard; Certified Reference Material

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Eprinomectin Pharmaceutical Secondary Standard; Certified Reference Material

PHR1766

Eprinomectin

Oxytetracycline Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

PHR1325

Oxytetracycline Hydrochloride

(±)-Miconazole nitrate salt Pharmaceutical Secondary Standard; Certified Reference Material

PHR1163

(±)-Miconazole nitrate salt

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

-10 to -25°C

storage temp.

2-30°C

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ivermectin is a derivative of avermectin B1 that is used against both endo- and ectoparasites in veterinary applications. It has also been indicated as a potential drug for the management of Onchocerca volvulus, identified as the cause of ′river blindness′ in humans.[1]

Application

Ivermectin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by chromatography techniques.[2][3]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA1636 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H300,H311,H410

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Ivermectin (3.15%) long-acting formulations in cattle: absorption pattern and pharmacokinetic considerations
    Lifschitz A, et al.
    Veterinary Parasitology, 147(3-4), 303-310 (2007)
    Ivermectin disposition kinetics after subcutaneous and intramuscular administration of an oil-based formulation to cattle
    Lifschitz A, et al.
    Veterinary Parasitology, 86(3), 203-215 (1999)
    Liquid chromatographic determination of ivermectin in animal plasma with trifluoroacetic anhydride and N-methylimidazole as the derivatization reagent
    de Montigny P, et al.
    Journal of Pharmaceutical and Biomedical Analysis, 8(6), 507-511 (1990)
    Feng Xiong et al.
    The Plant cell, 32(12), 3812-3824 (2020-09-30)
    Plant roots are sustained through meristem activity at the root tip. Two transcriptional pathways, one mediated by PLETHORAs (PLTs) and the other by SHORTROOT and SCARECROW, play major roles in root meristem development. The role of PLTs during root meristem

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