PHR1276
Niacin (Nicotinic Acid)
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Nicotinic acid, 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3
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About This Item
Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
Molecular Weight:
123.11
Beilstein:
109591
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to Ph. Eur. N0700000
traceable to USP 1461003
API family
nicotinic acid
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
236-239 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
OC(=O)c1cccnc1
InChI
1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChI key
PVNIIMVLHYAWGP-UHFFFAOYSA-N
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Niacin (Nicotinic Acid) is commonly used as a dietary supplement, and its deficiency can cause pellagra. It is involved in the synthesis of coenzymes such as NAD and NADP, which are quite essential for enzymatic reactions.
As a lipid-lowering agent, it helps in the prevention of coronary heart disease, carotid artery disease and other atherosclerotic vascular diseases.
As a lipid-lowering agent, it helps in the prevention of coronary heart disease, carotid artery disease and other atherosclerotic vascular diseases.
Application
Niacin (Nicotinic Acid) may be used as a secondary pharma standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAB7604 in the slot below. This is an example certificate only and may not be the lot that you receive.
Recommended products
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Product No.
Description
Pricing
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
WGK
WGK 1
Flash Point(F)
closed cup
Flash Point(C)
closed cup
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Development and Validation of RP-HPLC Method for the Estimation of Rosuvastatin Calcium and Niacin in Combined Tablet Dosage Form
MSN, et al.
International Journal of Pharma Research & Review, 4(6), 44-50 (2015)
Stabilities of dobutamine, dopamine, nitroglycerin and sodium nitroprusside in disposable plastic syringes.
Journal of Clinical Pharmacy and Therapeutics null
The Vitamin Cure: Clinically Proven Remedies to Prevent and Treat 75 Chronic Diseases and Conditions (2018)
Simultaneous determination of lovastatin and niacin in tablet by first and third derivative spectrophotometry and H-point standard addition methods
Kazemipour M, et al.
Research in Pharmaceutical Sciences, 7(2), 95-95 (2012)
Lucia Marcocci et al.
Antioxidants (Basel, Switzerland), 8(5) (2019-05-15)
Vitamin E nicotinate (tocopherol nicotinate, tocopheryl nicotinate; TN) is an ester of two vitamins, tocopherol (vitamin E) and niacin (vitamin B3), in which niacin is linked to the hydroxyl group of active vitamin E. This vitamin E ester can be
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