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PHR1035

Folic acid

Name: Folic acid
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₉N₇O₆

CAS Number:

59-30-3

Molecular Weight:

441.40

Beilstein:

100781

EC Number:

200-419-0

MDL number:

MFCD00079305

UNSPSC Code:

41116107

eCl@ss:

34058014

PubChem Substance ID:

329823065

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. F0300000
traceable to USP 1286005

API family

folic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Vitamin Standards

General description

Folic acid is mostly obtained from the diet itself or from pharmaceutical drugs such as vitamin pills.† It is highly necessary to consume folic acid for the prevention of neural tube defects, mainly anencephaly and spina bifida.† It belongs to the class of water soluble B vitamins called folates. It is mainly used to fortify cereals/grains and dietary supplements.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Folic acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using ultraviolet spectrophotometric technique and microemulsion electrokinetic chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7352 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Pricing

1286027

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10-Formylfolic acid, United States Pharmacopeia (USP) Reference Standard

1019870

4-Aminobenzoylglutamic acid, United States Pharmacopeia (USP) Reference Standard

BP937

Folic acid, British Pharmacopoeia (BP) Reference Standard

PHR2002

Folic Acid Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

Y0001979

Folic acid for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001980

Folic acid for impurity I identification, European Pharmacopoeia (EP) Reference Standard

PHR2001

Folic Acid Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

Y0002071

Calcium folinate for system suitability, European Pharmacopoeia (EP) Reference Standard

PHR2003

Folic Acid Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2334

10-Formylfolic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Quantitative determination of folic acid in multivitamin/multielement tablets using liquid chromatography/tandem mass spectrometry

Nelson.CB, et al.

Journal of Chromatography A, 1135, 203-211 (2006)

A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests

Matias R, et al.

Analytical Methods : Advancing Methods and Applications, 6(9), 3065-3071 (2014)

Determination of folic acid in tablets by microemulsion electrokinetic chromatography

Aurora-Prado SM, et al.

Journal of Chromatography A, 1051(1-2), 291-296 (2004)

In situ enrichment of folate by microorganisms in beta-glucan rich oat and barley matrices.

Susanna Kariluoto et al.

International journal of food microbiology, 176, 38-48 (2014-02-25)

The objective was to study folate production of yeast strains, bacteria isolated from oat bran, and selected lactic acid bacteria as well as one propionibacterium in oat and barley based models. Simultaneously, we aimed at sustaining the stability of viscosity

PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer.

R Wendel Naumann et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(35), 4400-4406 (2013-10-16)

Vintafolide (EC145) is a folic acid-desacetylvinblastine conjugate that binds to the folate receptor (FR), which is expressed on the majority of epithelial ovarian cancers. This randomized phase II trial evaluated vintafolide combined with pegylated liposomal doxorubicin (PLD) compared with PLD

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