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PHR1009

Supelco

Caffeine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

1,3,7-Trimethylxanthine

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1 KIT
CN¥3,340.17

About This Item

Empirical Formula (Hill Notation):
C8H10N4O2
CAS Number:
58-08-2
Molecular Weight:
194.19
Beilstein:
17705
MDL number:
MFCD00005758
UNSPSC Code:
12352210
PubChem Substance ID:
329823040
NACRES:
NA.24

CN¥3,340.17

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 766
traceable to Ph. Eur. C0100000
traceable to USP 1085003

API family

dimenhydrinate, caffeine, pentoxifylline

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

234-236.5 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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1 of 4

This Item
56396PHL89591205548
Caffeine Pharmaceutical Secondary Standard; Certified Reference Material

PHR1009

Caffeine

Caffeine certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

56396

Caffeine

Caffeine phyproof® Reference Substance

PHL89591

Caffeine

Caffeine Trimethylated xanthine that acts as a potent central nervous system stimulant.

205548

Caffeine

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

format

neat

format

neat

format

neat

format

-

Quality Level

300

Quality Level

300

Quality Level

-

Quality Level

100

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, TraceCERT®

grade

primary reference standard

grade

-

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

10-30°C

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Caffeine is an N-methyl derivative of xanthine and is involved in gastric acid secretion, diuresis, and stimulation of the central nervous system.[1]

Application

Caffeine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations,[1] blood plasma,[2] food, drinks, and herbal products[3] by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7780 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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C0100000

Caffeine, European Pharmacopoeia (EP) Reference Standard

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Y0000787

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D2000000

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Y0001103

Dimenhydrinate for peak identification, European Pharmacopoeia (EP) Reference Standard

1206006

Dimenhydrinate, United States Pharmacopeia (USP) Reference Standard

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Dimenhydrinate Related Compound E, United States Pharmacopeia (USP) Reference Standard

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Dimenhydrinate, Pharmaceutical Secondary Standard; Certified Reference Material

BP766

Caffeine, British Pharmacopoeia (BP) Reference Standard

PHR1999

Caffeine Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2000

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PHR1951

Caffeine Impurity E Nitrate (Caffeidine Nitrate), Pharmaceutical Secondary Standard; Certified Reference Material

PHR2038

Caffeine Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

BP1119

Diphenylmethanol, British Pharmacopoeia (BP) Reference Standard

PHR2117

4,4′-Difluorobenzophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3142

7-Methylxanthine, pharmaceutical secondary standard, certified reference material

PHR3218

Pentoxifylline, pharmaceutical secondary standard, certified reference material

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

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    Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products.
    Srdjenovic B, et al.
    Journal of Chromatographic Science, 46(2), 144-149 (2008)
    Simultaneous voltammetric determination of paracetamol and caffeine in pharmaceutical formulations using a boron-doped diamond electrode.
    Lourenc?o BC
    Talanta, 78(3), 748-752 (2009)
    Simultaneous determination of caffeine and non-steroidal anti-inflammatory drugs in pharmaceutical formulations and blood plasma by reversed-phase HPLC from linear gradient elution.
    Mart?n MJ, et al.
    Talanta, 49(2), 453-459 (1999)
    Markus Fehrholz et al.
    American journal of physiology. Lung cellular and molecular physiology, 306(1), L101-L109 (2013-10-29)
    Factors positively influencing surfactant homeostasis in general and surfactant protein B (SP-B) expression in particular are considered of clinical importance regarding an improvement of lung function in preterm infants. The objective of this study was to identify effects of physiological
    Pierre Ayotte et al.
    Environmental health perspectives, 113(10), 1318-1324 (2005-10-06)
    The Lower North Shore region of the St. Lawrence River is home to a fish-eating population that displays an unusually high body burden of several organochlorines, including polychlorinated biphenyls (PCBs) and dioxin-like compounds (DLCs). We measured biomarkers indicative of liver
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