P0510000
Pentoxifylline
European Pharmacopoeia (EP) Reference Standard
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Synonym(s):
3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental
Empirical Formula (Hill Notation):
C13H18N4O3
CAS Number:
Molecular Weight:
278.31
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
pharmaceutical primary standard
API family
pentoxifylline
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C
InChI
1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3
InChI key
MQGNNJQTNFHNHK-UHFFFAOYSA-N
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Pentoxifylline EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
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Product No.
Description
Pricing
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Lact.
WGK
WGK 3
Regulatory Information
监管及禁止进口产品
Certificates of Analysis (COA)
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Umair Sohail et al.
Clinics in liver disease, 16(4), 717-736 (2012-10-30)
Alcoholic hepatitis is a form of severe, cholestatic liver disease that results from consumption of large amount of alcohol during a sustained period of time in a subset of alcoholics. Symptoms could be mild and nonspecific to more severe. The diagnosis
Saad Hamama et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 105(3), 305-312 (2012-10-02)
Radiation-induced fibrosis is a serious late complication of radiotherapy. Pentoxifylline-vitamin E has proven effective and safe in clinical trials in the treatment of fibrosis, while the molecular mechanism of its activity is yet unexplored. Ten patients suffering from radiation-induced enteropathy
John M Akudugu et al.
International journal of radiation biology, 89(6), 462-470 (2013-02-01)
The mode by which the xanthine derivative, pentoxifylline, induces a radiosensitizing effect in cell cultures is a key and controversial radiobiological issue and requires further elucidation. Six human glioblastoma cell lines were tested for the effect of pentoxifylline treatment at
Donghao Lv et al.
The Cochrane database of systematic reviews, (3)(3), CD007677-CD007677 (2009-07-10)
Endometriosis is a chronic, recurring condition that occurs during the reproductive years. It is characterized by endometrial tissue developing outside the uterine cavity. This endometrial tissue development is dependent on estrogen produced primarily by the ovaries and, therefore, traditional management
Donghao Lu et al.
The Cochrane database of systematic reviews, 1, CD007677-CD007677 (2012-01-20)
Endometriosis is a chronic, recurring condition that occurs during the reproductive years. It is characterized by endometrial tissue developing outside the uterine cavity. This endometrial tissue development is dependent on oestrogen produced primarily by the ovaries and, therefore, traditional management
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