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N0850000

Nimodipine

Name: Nimodipine
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₆N₂O₇

CAS Number:

66085-59-4

Molecular Weight:

418.44

MDL number:

MFCD00153848

UNSPSC Code:

41116107

PubChem Substance ID:

329818466

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

nimodipine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C

InChI

1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3

InChI key

UIAGMCDKSXEBJQ-UHFFFAOYSA-N

Gene Information

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , NR3C2(4306)

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Related Categories

Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nimodipine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

N0850010

Nimodipine impurity A, European Pharmacopoeia (EP) Reference Standard

1463870

1463858

Nimodipine, United States Pharmacopeia (USP) Reference Standard

1463869

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Lot/Batch Number

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Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage: a systematic review.

Mervyn D I Vergouwen et al.

The Lancet. Neurology, 5(12), 1029-1032 (2006-11-18)

Despite several randomised controlled trials, there is still much debate whether nimodipine improves outcome in patients with traumatic subarachnoid haemorrhage. A 2003 Cochrane review reported improved outcome with nimodipine in these patients; however, because the results of Head Injury Trial

Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review.

J Horn et al.

Stroke, 32(10), 2433-2438 (2001-10-06)

Based on the results of animal experiments, clinical trials were performed with nimodipine, which did not demonstrate a beneficial effect on outcome after stroke. The aim of this study was to determine whether the evidence from animal experiments with nimodipine

Potential interactions between nimodipine and adrenal hormones.

R L Isaacson et al.

Annals of the New York Academy of Sciences, 765, 134-142 (1995-09-15)

Bioanalytics of nimodipine--an overview of methods.

W Mück et al.

Die Pharmazie, 49(2-3), 130-139 (1994-02-01)

The analytical test procedures currently established for the determination of the dihydropyridine calcium antagonist nimodipine in biological fluids are presented. Method of choice which has been dominantly used in pharmacokinetic investigations and drug interaction studies is gas chromatography with electron-capture

Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.

Bin Pan et al.

The Journal of pharmacology and experimental therapeutics, 350(2), 290-300 (2014-06-04)

Sigma-1 receptor (σ1R), an endoplasmic reticulum-chaperone protein, can modulate painful response after peripheral nerve injury. We have demonstrated that voltage-gated calcium current is inhibited in axotomized sensory neurons. We examined whether σ1R contributes to the sensory dysfunction of voltage-gated calcium

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