D8809
Daunorubicin hydrochloride
meets USP testing specifications
Recommended Products
Agency
USP/NF
meets USP testing specifications
Quality Level
form
solid
antibiotic activity spectrum
neoplastics
Mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
InChI
1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChI key
GUGHGUXZJWAIAS-QQYBVWGSSA-N
Gene Information
human ... TOP2A(7153)
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Related Categories
Biochem/physiol Actions
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
WGK
WGK 3
Personal Protective Equipment
Regulatory Information
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is this compound soluble in?
Per Martindale The Extra Pharmacopoeia, 31st edition, p. 565-3 (1996), this compound is freely soluble in water and methyl alcohol. It is slightly soluble in alcohol, very slightly soluble in chloroform, and practically insoluble in acetone.
What factors affect the stability of Product No. D8809, Daunorubicin hydrochloride, in solution?
Per Martindale The Extra Pharmacopoeia, 31st edition, p. 565-3 (1996), stability in solution appeared to be partly related to pH. Daunorubicin was more stable as the pH of the mixture became more acidic, with the best stability in glucose injection solution (5%) with a pH of 4.5 Although daunorubicin solutions are degraded by light, the effect is reported not to be significant at concentrations of 500 ug/mL or above. However, below this concentration, precautions should be taken to protect solutions from light, and storage should be in polyethylene or polypropylene containers to minimize adsorptive losses.
Does Product No. D8809, Daunorubicin hydrochloride, have an expiration date?
Yes, each lot of this product will have an expiration date, and this date (month and year) can be found on the certificate of analysis for the lot.
Does the assay information on the certificate of analysis for Product No. D8809, Daunorubicin hydrochloride, pertain to a "dry" or "as is" basis?
The assay information on the certificate of analysis is for the product "as is".
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