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D3281

Supelco

Diflunisal

analytical standard

Synonym(s):

2′,4′-Difluoro-4-hydroxy-[1,1′-biphenyl]-3-carboxylic acid, 5-(2,4-Difluorophenyl)salicylic acid

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About This Item

Empirical Formula (Hill Notation):
C13H8F2O3
CAS Number:
22494-42-4
Molecular Weight:
250.20
EC Number:
245-034-9
MDL number:
MFCD00057834
UNSPSC Code:
41116107
PubChem Substance ID:
329798693
NACRES:
NA.24

grade

analytical standard

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

FC1=CC(F)=CC=C1C2=CC(C(O)=O)=C(O)C=C2

InChI

1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18)

InChI key

HUPFGZXOMWLGNK-UHFFFAOYSA-N

Gene Information

human ... ALB(213) , PTGS1(5742) , PTGS2(5743)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335,H361

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW3470
MKCQ1736
MKCM4294
MKCK9268
MKCH2787

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Francesco Castelli et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 35(1-2), 76-85 (2008-07-16)
Inulin has been derivatized with methacrylic anhydride (MA) and succinic anhydride (SA) to obtain a methacrylated/succinilated derivative (INU-MA-SA) able to produce a pH sensitive hydrogel after UV irradiation. The hydrogel was characterized and loaded with diflunisal (10.4, 17 and 24%
John L Berk et al.
JAMA, 310(24), 2658-2667 (2013-12-26)
Familial amyloid polyneuropathy, a lethal genetic disease caused by aggregation of variant transthyretin, induces progressive peripheral nerve deficits and disability. Diflunisal, a nonsteroidal anti-inflammatory agent, stabilizes transthyretin tetramers and prevents amyloid fibril formation in vitro. To determine the effect of
Hsuan-Lei Sung et al.
Colloids and surfaces. B, Biointerfaces, 109, 68-73 (2013-04-30)
Three microemulsion systems were applied as solvents for polymorph screening of seven active pharmaceutical ingredients (APIs): carbamazepine, piroxicam, sulfaguanidine, nitrofurantoin, theophylline, quercetin, and diflunisal. All the recrystallized compounds were examined by using powder X-ray diffractometry, differential scanning calorimetry, elemental analysis
Maria Esther Zugasti et al.
Drug development and industrial pharmacy, 35(10), 1264-1270 (2009-06-27)
The influence of beta-cyclodextrin (beta-CD) polymers on drug release from hydroxypropyl methylcellulose (HPMC) matrices has not been reported in the literature. The influence of monomeric beta-CD and both soluble and insoluble beta-CD polymers on drug release from tablets containing either
Teresa Mairal et al.
PloS one, 4(1), e4124-e4124 (2009-01-07)
The thyroid hormone and retinol transporter protein known as transthyretin (TTR) is in the origin of one of the 20 or so known amyloid diseases. TTR self assembles as a homotetramer leaving a central hydrophobic channel with two symmetrical binding
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