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COO/COA

C3090000

Cyclizine hydrochloride

Name: Cyclizine hydrochloride
Brand: SIAL

(European Pharmacopoeia (EP) Reference Standard)

Synonym(s):

1-Benzhydryl-4-methylpiperazine hydrochloride, Marezine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₂N₂ · HCl

CAS Number:

303-25-3

Molecular Weight:

302.84

UNSPSC Code:

41116107

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

cyclizine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H

InChI key

UKPBEPCQTDRZSE-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cyclizine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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1154015

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1051602

Benzhydrol, United States Pharmacopeia (USP) Reference Standard

BP096

Cyclizine hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR2071

Benzhydrol, Pharmaceutical Secondary Standard; Certified Reference Material

BP1118

1-Methylpiperazine, British Pharmacopoeia (BP) Reference Standard

Pictograms

GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.

Shigeru Hishinuma et al.

Biochemical pharmacology, 91(2), 231-241 (2014-07-30)

Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human

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