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COO/COA

1154004

USP

Cyclizine hydrochloride

Name: Cyclizine hydrochloride
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1-Benzhydryl-4-methylpiperazine hydrochloride, Marezine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₂N₂ · HCl

CAS Number:

303-25-3

Molecular Weight:

302.84

UNSPSC Code:

41116107

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

cyclizine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H

InChI key

UKPBEPCQTDRZSE-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Apoptotic pathways in macrophages: Cyclizine hydrochloride was studied for its ability to induce cytotoxicity and apoptosis in macrophages through both extrinsic and intrinsic pathways, suggesting its potential implications in immunomodulatory therapies (Lu et al., 2024).

Chemometric methods in impurity analysis: Advanced chemometric methods have been employed to determine cyclizine hydrochloride along with other compounds in pharmaceutical products, highlighting its importance in ensuring the purity and efficacy of drug formulations (Saad et al., 2022).

Anti-inflammatory effects in pharmacology: Cyclizine derivatives were synthesized and evaluated for anti-inflammatory performance on Wistar rats, providing insights into the therapeutic potential of cyclizine modifications in treating inflammation (Ahmadi et al., 2012).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1154015

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1051602

Benzhydrol, United States Pharmacopeia (USP) Reference Standard

BP096

Cyclizine hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR2071

Benzhydrol, Pharmaceutical Secondary Standard; Certified Reference Material

BP1118

1-Methylpiperazine, British Pharmacopoeia (BP) Reference Standard

Pictograms

GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.

Shigeru Hishinuma et al.

Biochemical pharmacology, 91(2), 231-241 (2014-07-30)

Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human

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