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BP576

Hydrocortisone

British Pharmacopoeia (BP) Assay Standard

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Synonym(s):
11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
Empirical Formula (Hill Notation):
C21H30O5
CAS Number:
50-23-7
Molecular Weight:
362.46
Beilstein:
1354819
MDL number:
MFCD00011654
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

hydrocortisone

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

211-214 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... NR3C1(2908)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Tretinoin, Hydrocortisone and Hydroquinone Cream
  • Miconazole and Hydrocortisone Acetate Cream
  • Hydrocortisone Sodium Succinate Injection
  • Prednisolone Tablets
  • Miconazole and Hydrocortisone Cream
  • Miconazole and Hydrocortisone Ointment
  • Hydrocortisone and Neomycin Cream
  • Hydrocortisone and Clioquinol Ointment
  • Hydrocortisone Sodium Phosphate Oral Solution
  • Prednisolone Gastro-resistant Tablets
  • Hydrocortisone Sodium Phosphate
  • Hydrocortisone Sodium Phosphate Injection
  • Hydrocortisone and Clioquinol Cream
  • Methylprednisolone Tablets
  • Hydrocortisone Acetate Oral Suspension
  • Hydrocortisone Cream
  • Hydrocortisone Oromucosal Tablets

    • Biochem/physiol Actions

    Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

    Other Notes

    Sales restrictions may apply.

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    PHR2160

    Hydrocortisone Impurity J, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2157

    Hydrocortisone Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2162

    Hydrocortisone Impurity L, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2161

    Hydrocortisone Impurity K, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2159

    Hydrocortisone Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2163

    Hydrocortisone Impurity M, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2158

    Hydrocortisone Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2164

    6a-Hydroxyhydrocortisone, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2156

    Hydrocortisone Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR3185

    Hydrocortisone Valerate, pharmaceutical secondary standard, certified reference material

    Pictograms

    Health hazard
    GHS08

    Signal Word

    Danger

    Hazard Statements

    H360Df,H373

    Hazard Classifications

    Repr. 1A - STOT RE 2

    Target Organs

    Adrenal gland,Bone marrow

    WGK

    WGK 2

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Regulatory Information

    监管及禁止进口产品

    Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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