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Merck
CN

49431

Dichloroacetic acid solution

suitable for DNA synthesis, 3% in methylene chloride

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About This Item

Empirical Formula (Hill Notation):
C2H2Cl2O2
CAS Number:
79-43-6
Molecular Weight:
128.94
PubChem Substance ID:
329757449
UNSPSC Code:
12161700
Beilstein/REAXYS Number:
1098596
MDL number:
MFCD00004223
Concentration:
3% in methylene chloride
Grade:
synthesis grade

Key Documents

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SMILES string

OC(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)

InChI key

JXTHNDFMNIQAHM-UHFFFAOYSA-N

grade

synthesis grade

concentration

3% in methylene chloride

technique(s)

DNA synthesis: suitable

impurities

≤0.01% water

density

1.335 g/mL at 20 °C

Gene Information

human ... ALDH1A1(216), PDK1(5163)
rat ... Pdk1(116551)

General description

filtered through a 1 μm filter

Application

Reagent used in the phosphite triester method of oligonucleotide synthesis for the cleavage of the 5′-protecting group. Reagent is suitable for use on Milligen 7500 synthesizers or as a more mildly acidic alternative to trichloroacetic acid.

signalword

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

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Yi-Hsueh Chuang et al.
Water research, 47(3), 1308-1316 (2013-01-05)
The direct incorporation of chloramines and dissolved organic nitrogen (DON) may provide the nitrogen for nitrogenous disinfection byproducts (N-DBPs). This study explores the contributions of natural DON and chloramine incorporation to the formation of N-DBPs during chloramination. This study also
Mehdi D Esrafili
Journal of molecular modeling, 18(12), 5005-5016 (2012-06-28)
A theoretical study was performed to examine hydrogen and halogen bonds properties in gas phase and crystalline dichloroacetic acid (DCAA). The specific pattern of O-H∙∙∙O, C-H∙∙∙O, HCl, Cl∙∙∙O and Cl∙∙∙Cl interactions in DCAA dimers is described within the quantum theory
Haihua Xiao et al.
Chemical communications (Cambridge, England), 48(87), 10730-10732 (2012-09-27)
A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.
Yong Won Choi et al.
Cancer letters, 346(2), 300-308 (2014-02-01)
To investigate sensitization of metformin-cytotoxicity, cancer cells were treated with dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK). Metformin-cytotoxicity was mainly dependent on glucose availability and reducing power generated by pentose phosphate pathway, whereas DCA cotreatment enhanced metformin-cytotoxicity via
Jae Mo Park et al.
Neuro-oncology, 15(4), 433-441 (2013-01-19)
The metabolic phenotype that derives disproportionate energy via glycolysis in solid tumors, including glioma, leads to elevated lactate labeling in metabolic imaging using hyperpolarized [1-(13)C]pyruvate. Although the pyruvate dehydrogenase (PDH)-mediated flux from pyruvate to acetyl coenzyme A can be indirectly
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