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33742

Sigma-Aldrich

Trizma® base

≥99.5%, crystalline, puriss p.a., aminopeptidase substrate

Synonym(s):

2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Tris(hydroxymethyl)aminomethane, Trometamol

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About This Item

Linear Formula:
NH2C(CH2OH)3
CAS Number:
77-86-1
Molecular Weight:
121.14
Beilstein:
741883
EC Number:
201-064-4
MDL number:
MFCD00004679
UNSPSC Code:
12352104
PubChem Substance ID:
329754644

product name

Trizma® base, puriss. p.a., buffer substance, ≥99.5%

description

aminopeptidase substrate

grade

puriss. p.a.

Assay

≥99.5%

form

crystalline

impurities

≤0.0005% heavy metals (as Pb)
≤0.5% water (Karl Fischer)

ign. residue

≤0.05% (as SO4)

color

white

pH

10.3-10.8 (0.1 M)

useful pH range

7-9

pKa (25 °C)

8.1

bp

219-220 °C/10 mmHg (lit.)

mp

167-172 °C (lit.)
168-172 °C

solubility

water: soluble (678 g/l at 20 °C)

anion traces

chloride (Cl-): ≤5 mg/kg
sulfate (SO42-): ≤10 mg/kg

cation traces

Fe: ≤5 mg/kg

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

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Other Notes

The pH values of all buffers are temperature- and concentration-dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution.
For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.

Legal Information

Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBS6842
BCBR9475V
BCBR9475
SZBF1110V
SZBE3030V

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