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Safety Information

33709

Sigma-Aldrich

Tetrahydrofuran

≥99.9% (GC), contains ~250 mg/L 2, 6-di-tert.-butyl-4-methylphenol as stabilizer, puriss. p.a.

Synonym(s):

THF, Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
109-99-9
Molecular Weight:
72.11
Beilstein:
102391
EC Number:
203-726-8
MDL number:
MFCD00005356
UNSPSC Code:
12352005
PubChem Substance ID:
57648904
Assay:
≥99.9% (GC)
bp:
65-67 °C (lit.)
vapor pressure:
114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

Product Name

Tetrahydrofuran, puriss. p.a., ≥99.9% (GC)

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

grade

puriss. p.a.

Assay

≥99.9% (GC)

form

liquid

autoignition temp.

610 °F

contains

~250 mg/L 2,6-di-tert.-butyl-4-methylphenol as stabilizer

expl. lim.

1.8-11.8 %

impurities

≤0.001% free acid (as CH3COOH)
≤0.001% non-volatile matter
≤0.005% peroxides (as H2O2)
≤0.05% water (Karl Fischer)

color

APHA: <20

refractive index

n20/D 1.407 (lit.)

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

solubility

H2O: soluble

density

0.889 g/mL at 25 °C (lit.)

cation traces

Al: ≤0.5 mg/kg
B: ≤0.02 mg/kg
Ba: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Ni: ≤0.02 mg/kg
Pb: ≤0.1 mg/kg
Sn: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

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General description

Tetrahydrofuran (THF) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms a double hydrate with hydrogen sulfide. The crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.

Application

Tetrahydrofuran has been used for the dissolution of poly-ε-caprolactone (PCL), during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds. It has been used for the dissolution of 1,3-diaminopentane, during the synthesis of acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)-1,3-diaminopentane (117) polymer.

Packaging

bottled under inert gas

Other Notes

Go to our Greener Alternative-2-Methyl Tetrahydrofuran

Go to our Greener Alternative-Cyclopentyl methylether

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.

recommended

Product No.
Description
Pricing

suggested gloves for splash protection

Product No.
Description
Pricing

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system, Respiratory system

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-6.2 °F - closed cup

Flash Point(C)

-21.2 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SZBA360S
SZBA360SV
SZBB114SV
SZBA365SV
SZBA365S

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Todd J Harris et al.
Biomaterials, 31(5), 998-1006 (2009-10-24)
The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant concern is that the interior and
Haiying Yu et al.
Biomaterials, 30(4), 508-517 (2008-11-01)
Natural bone growth greatly depends on the precedent vascular network that supplies oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue-engineered bone to establish a vascular network that temporally precedes new bone formation, and spatially originates
Polyhedral clathrate hydrates. X. Structure of the double hydrate of tetrahydrofuran and hydrogen sulfide.
Mak TCW, et al.
J. Chem. Phys. , 42(8), 2732-2737 (1965)
Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products.
Boivin TLB.
Tetrahedron, 43(15), 3309-3362 (1987)
P T Clayton et al.
The Journal of clinical investigation, 79(4), 1031-1038 (1987-04-01)
Urinary bile acids from a 3-mo-old boy with cholestatic jaundice were analyzed by ion exchange chromatography and gas chromatography-mass spectrometry (GC-MS). This suggested the presence of labile sulfated cholenoic acids with an allylic hydroxyl group, a conclusion supported by analysis
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