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34865

Sigma-Aldrich

Tetrahydrofuran

≥99.9%, suitable for HPLC, inhibitor-free

Synonym(s):

THF, Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
109-99-9
Molecular Weight:
72.11
Beilstein:
102391
EC Number:
203-726-8
MDL number:
MFCD00005356
UNSPSC Code:
41116105
PubChem Substance ID:
329755073
NACRES:
NA.21

product name

Tetrahydrofuran, inhibitor-free, suitable for HPLC, ≥99.9%

vapor density

2.5 (vs air)

Quality Level

100

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

Assay

≥99.9%

form

liquid

autoignition temp.

610 °F

expl. lim.

1.8-11.8 %

technique(s)

HPLC: suitable

impurities

≤0.0005% non-volatile matter
≤0.002% free acid (as CH3COOH)
≤0.05% peroxides (as H2O2)
≤0.05% water (Karl Fischer)

evapn. residue

≤0.0005%

color

APHA: ≤10

refractive index

n20/D 1.407 (lit.)

pH

~7

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

density

0.889 g/mL at 25 °C (lit.)

absorption

≤0.0044 at 315 nm
≤0.005 at 350 nm
≤0.005 at 400 nm
≤0.02 at 300 nm
≤0.046 at 275 nm
≤0.18 at 250 nm
≤0.26 at 245 nm
≤1.0 at 212 nm

UV absorption

λ: 245 nm Amax: ≤0.26
λ: 275 nm Amax: ≤0.046
λ: 315 μm Amax: ≤0.0044

suitability

complies for IR spectroscopy

application(s)

food and beverages

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

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General description

Tetrahydrofuran (THF) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1,4-diol is formed as an intermediate during the synthesis of THF. Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV).

Application

Suitable for HPLC, spectrophotometry, environmental testing
Tetrahydrofuran may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds and acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)- 1,3-diaminopentane (117) polymer, respectively.

Other Notes

Important notice
  • The article number 34865-4X2.5L will be discontinued. Please order the single bottle 34865-2.5L which is physically identical with the same exact specifications.
  • The article number 34865-6X1L will be discontinued. Please order the single bottle 34865-1L which is physically identical with the same exact specifications.

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Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system, Respiratory system

Supplementary Hazards

EUH019

WGK

WGK 1

Flash Point(F)

-6.2 °F

Flash Point(C)

-21.2 °C

Regulatory Information

危险化学品

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Todd J Harris et al.
Biomaterials, 31(5), 998-1006 (2009-10-24)
The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant concern is that the interior and
Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products.
Boivin TLB.
Tetrahedron, 43(15), 3309-3362 (1987)
Eagleson M.
Concise Encyclopedia Chemistry, 152-152 (1994)
Eagleson M.
Concise Encyclopedia Chemistry, 883-883 (1994)
Soni Khandelwal et al.
International journal of molecular sciences, 19(11) (2018-10-31)
Within the subtypes of breast cancer, those identified as triple negative for expression of estrogen receptor α (ESR1), progesterone receptor (PR) and human epidermal growth factor 2 (HER2), account for 10⁻20% of breast cancers, yet result in 30% of global
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