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Key Documents

Safety Information

2106

Sigma-Aldrich

Heparin sodium salt from porcine intestinal mucosa

endotoxin, free

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About This Item

CAS Number:
9041-08-1
MDL number:
MFCD00081689
UNSPSC Code:
12352201
NACRES:
NA.21
Pricing and availability is not currently available.

biological source

Porcine intestinal mucosa

Quality Level

200

form

powder

usage

sufficient for 5 mL blood anticoagulant

packaging

preweighed vial of 300 USP units

impurities

endotoxin, free

color

beige

solubility

water: soluble 50 g/L
acetone: insoluble
alcohol: insoluble
benzene: insoluble
chloroform: insoluble
diethyl ether: insoluble

compatibility

for use with E-Toxate™

storage temp.

room temp

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application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

application(s)

environmental
food and beverages

application(s)

environmental
food and beverages

application(s)

environmental
food and beverages

format

single component solution

format

single component solution

format

single component solution

format

single component solution

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

product line

TraceCERT®

product line

TraceCERT®

product line

TraceCERT®

product line

TraceCERT®

concentration

1000 mg/L lactate in water (nominal concentration)

concentration

1000 mg/L in water (nominal concentration)

concentration

1000 mg/L in water (nominal concentration)

concentration

1000 mg/L gluconate in water (nominal concentration)

Application

Heparin sodium salt from porcine intestinal mucosa has been used as a M199 medium supplement used for maintaining human umbilical vein endothelial cells.[1]

Biochem/physiol Actions

Heparin sodium salt is the salt form of heparinic acid and is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is an anticoagulant that produces its major anticoagulant effect by activating antithrombin. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor and accelerates significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (factor Xa and thrombin).[2][3][4] Additionally, it also facilitates the stabilization and regulation of tryptase as an enzymatically active tetramer.[5]

Caution

Not for injection.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Legal Information

E-Toxate is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000403947
    0000403947
    0000260909
    0000260909
    SLCQ6590

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    Nada M S Al-Saffar et al.
    British journal of cancer, 119(9), 1118-1128 (2018-11-01)
    AKT is commonly overexpressed in tumours and plays an important role in the metabolic reprogramming of cancer. We have used magnetic resonance spectroscopy (MRS) to assess whether inhibition of AKT signalling would result in metabolic changes that could potentially be
    Mechanism of the anticoagulant action of heparin.
    I Björk et al.
    Molecular and cellular biochemistry, 48(3), 161-182 (1982-10-29)
    D Beeler et al.
    The Journal of biological chemistry, 254(8), 2902-2913 (1979-04-25)
    Preparations of low molecular weight porcine heparin with an average specific anticoagulant activity of 94 units/mg were fractionated into "active" and "relatively inactive" forms of the mucopolysaccharide of approximately 6000 daltons each. The active fraction was further subdivided into various
    Overexpression of Functional SLC6A3 in Clear Cell Renal Cell Carcinoma.
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    Clinical cancer research : an official journal of the American Association for Cancer Research, 23(8), 2105-2115 (2016-09-25)
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    Journal of assisted reproduction and genetics, 37(9), 2105-2117 (2020-07-28)
    To investigate if human ovarian grafting with pure virgin human recombinant collagen type-1 from bioengineered plant lines (CollPlant™) or small intestine submucosa (SIS) yields better implantation results for human ovarian tissue and which method benefits more when combined with the
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