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11332

Atropine sulfate salt monohydrate

Name: Atropine sulfate salt monohydrate
Brand: SIAL

tested according to Ph. Eur.

Synonym(s):

Atropini sulfas, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate

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About This Item

Linear Formula:

(C₁₇H₂₃NO₃)₂ · H₂SO₄ · H₂O

CAS Number:

5908-99-6

Molecular Weight:

694.83

UNSPSC Code:

12352200

NACRES:

NA.21

PubChem Substance ID:

329749385

EC Number:

200-235-0

Beilstein/REAXYS Number:

6109275

MDL number:

MFCD00074815

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Properties

Quality Level

200

agency

USP/NF, tested according to Ph. Eur.

mp

189-192 °C (A) (lit.)

solubility

water: soluble 2500 g/L at 4 °C

application(s)

pharmaceutical (small molecule)

SMILES string

O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6

InChI

1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

InChI key

JPKKQJKQTPNWTR-CHYDPLAESA-N

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131)

Description

Application

Atropine sulfate salt monohydrate has been used for anaesthetizing mice for intranasal administration of ropinirole or 7-OH-DPAT.

Biochem/physiol Actions

Atropine sulfate salt monohydrate is a competitive nonselective antagonist of central and peripheral muscarinic acetylcholine receptors. Atropine is a cholinergic receptor antagonist isolated from Atropa belladona L., Datura stramonium L. and other plants of the solanaceae family. It blocks the ion currents mediated by neuronal nicotinic acetylcholine receptors. Further, it blocks the acetylcholine (ACh)-induced relaxations in human pulmonary veins.

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

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pictograms

GHS06

signalword

Danger

hcodes

H300 + H330

pcodes

P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins.

L Walch et al.

British journal of pharmacology, 130(1), 73-78 (2000-04-26)

1. To characterize the muscarinic receptors on human pulmonary veins associated with the acetylcholine (ACh)-induced relaxation, isolated venous and arterial preparations were pre-contracted with noradrenaline (10 microM) and were subsequently challenged with ACh in the absence or presence of selective

Pharmacological profile of CEB-1957 and atropine toward brain muscarinic receptors and comparative study of their efficacy against sarin poisoning.

F Trovero et al.

Toxicology and applied pharmacology, 150(2), 321-327 (1998-07-07)

This study consists of two parts, first to compare the pharmacological profile of atropine and CEB-1957 substance toward muscarinic receptor subtypes. In various rat brain structures, binding properties were determined by competition experiments of [3H]pirenzepine, [3H]AF-DX 384, and [3H]4-DAMP in

Potentiation and inhibition of neuronal nicotinic receptors by atropine: competitive and noncompetitive effects.

R Zwart et al.

Molecular pharmacology, 52(5), 886-895 (1997-11-14)

Atropine, the classic muscarinic receptor antagonist, inhibits ion currents mediated by neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. At the holding potential of -80 mV, 1 microM atropine inhibits 1 mM acetylcholine-induced inward currents mediated by rat alpha2beta2

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Global Trade Item Number

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