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Merck
CN

10816

Apramycin sulfate salt

~95% (TLC)

Synonym(s):

Nebramycin II

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About This Item

Empirical Formula (Hill Notation):
C21H41N5O11 · xH2SO4
CAS Number:
65710-07-8
Molecular Weight:
539.58 (free base basis)
EC Number:
265-890-7
UNSPSC Code:
51101500
MDL number:
MFCD06200257

Key Documents

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InChI key

WGLYHYWDYPSNPF-RQFIXDHTSA-N

InChI

1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1

SMILES string

OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O

assay

~95% (TLC)

technique(s)

UV/Vis spectroscopy: suitable

impurities

≤10% water

mode of action

protein synthesis | interferes

General description

Chemical structure: aminoglycoside

Other Notes

Effects on bacterial protein synthesis

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品
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S Perzynski et al.
European journal of biochemistry, 99(3), 623-628 (1979-09-01)
1. The novel aminoglycoside antibiotic apramycin is shown to be a potent inhibitor of protein synthesis in bacteria both in vivo and in vitro. 2. In cell-free systems from Escherichia coli programmed with poly(U), apramycin induces translation errors, as assayed

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