All Photos(1)
Synonym(s):
mPEG-NH2, O-(2-Aminoethyl)-O′-methylpolyethylene glycol, Aminopolyethylene glycol monomethyl ether, Methoxypolyoxyethylene amine
Linear Formula:
H2NCH2CH2(OCH2CH2)nOCH3
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Quality Level
form
solid
color
white to yellow
InChI
1S/C3H9NO/c1-5-3-2-4/h2-4H2,1H3
InChI key
ASUDFOJKTJLAIK-UHFFFAOYSA-N
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Related Categories
Application
Methoxypolyethylene glycol amine can:
- Form dendritic micelles to enhance the solubility of hydrophobic compounds.
- Conjugate with an anticancer drug methotrexate (MTX) to form MTX-PEG with potential application as drug carriers.
- Couple with polyethylenimine (PEI) to form graft copolymers which can be used as nonviral gene vectors.
Other Notes
Oligomer used to prepare PEG-ylated conjugates having the advantage of reduced immunogenicity and increased serum half life
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Polyethylene glycol-polyamidoamine dendritic micelle as solubility enhancer and the effect of the length of polyethylene glycol arms on the solubility of pyrene in water.
Yang H, et al.
Journal of Colloid and Interface Science, 273(1), 148-154 (2004)
T.P. Kogan
Synthetic Communications, 22, 2417-2417 (1992)
Polyethylene Glycol Conjugates of Methotrexate Varying in Their Molecular Weight from MW 750 to MW 40000: Synthesis, Characterization, and Structure- Activity Relationships in Vitro and in Vivo.
Riebeseel K, et al.
Bioconjugate Chemistry, 13(4), 773-785 (2002)
Effect of polyethylene glycol on gene delivery of polyethylenimine.
Sung SJ, et al.
Biological & Pharmaceutical Bulletin, 26(4), 492-500 (2003)
M Yokoyama et al.
Bioconjugate chemistry, 3(4), 295-301 (1992-07-01)
Adriamycin, a hydrophobic anticancer drug, was conjugated with poly(ethylene oxide)-poly(aspartic acid) block copolymers composed of various lengths of each block copolymer segment ranging from 1000 to 12,000 in molecular weight and from 10 to 80 units, respectively. Conjugation was achieved
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