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03762

2,6-Di-tert-butyl-4-methylphenol

Name: 2,6-Di-<I>tert</I>-butyl-4-methylphenol
Brand: SIAL

tested according to Ph. Eur.

Synonym(s):

Butylhydroxytoluenum, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

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About This Item

Linear Formula:

[(CH₃)₃C]₂C₆H₂(CH₃)OH

CAS Number:

128-37-0

Molecular Weight:

220.35

Beilstein:

1911640

EC Number:

204-881-4

MDL number:

MFCD00011644

UNSPSC Code:

12352300

PubChem Substance ID:

329747800

NACRES:

NA.21

Agency

USP/NF
tested according to Ph. Eur.

Quality Level

200

vapor density

7.6 (vs air)

vapor pressure

<0.01 mmHg ( 20 °C)

autoignition temp.

878 °F

bp

265 °C (lit.)

mp

69-73 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

InChI key

NLZUEZXRPGMBCV-UHFFFAOYSA-N

Gene Information

human ... CAPN1(823)
rat ... Capn1(29153) , Nos1(24598)

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Application

Quantitative analysis of residual butylated hydroxytoluene and butylated hydroxyanisole in Salmo salar, milk, and butter by liquid chromatography-tandem mass spectrometry.: This study provides a quantitative analysis of residual 2,6-Di-tert-butyl-4-methylphenol (BHT) and butylated hydroxyanisole (BHA) in various food products. The research highlights the presence and concentration of these antioxidants in fish, milk, and butter, demonstrating their widespread use in food preservation (Galal et al., 2024).

The key factors of solid nanodispersion for promoting the bioactivity of abamectin.: This research investigates the use of BHT in solid nanodispersions to enhance the bioactivity of abamectin, a widely used insecticide. The study identifies key factors that improve the stability and effectiveness of the formulation, suggesting applications in agricultural biotechnology (Ding et al., 2024).

Pictograms

GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

WGK

WGK 2

Flash Point(F)

260.6 °F

Flash Point(C)

127 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model.

Li Li et al.

Circulation, 105(7), 861-867 (2002-02-21)

Current epidemiological data suggest that dental infections affecting tooth-supporting tissues (periodontitis) can disseminate into the systemic circulation and thereby contribute to atherosclerosis progression. To test this hypothesis, we investigated the effect of repeated systemic inoculations with Porphyromonas gingivalis (Pg), a

The antioxidant butylated hydroxytoluene protects against atherosclerosis.

I Björkhem et al.

Arteriosclerosis and thrombosis : a journal of vascular biology, 11(1), 15-22 (1991-01-01)

Rabbits fed a 1% cholesterol diet with or without the antioxidant butylated hydroxytoluene (BHT) developed typical atherosclerotic lesions. The addition of BHT gave higher levels of total cholesterol (+40%), triglycerides (+250%), low density lipoprotein (LDL), and very low density lipoprotein

Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents.

A M Vijesh et al.

European journal of medicinal chemistry, 46(11), 5591-5597 (2011-10-05)

In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized

Effects of feeding Spodoptera littoralis on lima bean leaves: IV. Diurnal and nocturnal damage differentially initiate plant volatile emission.

Gen-ichiro Arimura et al.

Plant physiology, 146(3), 965-973 (2008-01-01)

Continuous mechanical damage initiates the rhythmic emission of volatiles in lima bean (Phaseolus lunatus) leaves; the emission resembles that induced by herbivore damage. The effect of diurnal versus nocturnal damage on the initiation of plant defense responses was investigated using

Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT).

H Witschi et al.

Pharmacology & therapeutics, 42(1), 89-113 (1989-01-01)

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