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Safety Information

02644

Sigma-Aldrich

7-Ethoxycoumarin

for fluorescence, ≥99.0% (HPLC)

Synonym(s):

7-Ethoxy-1-benzopyran-2-one

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About This Item

Empirical Formula (Hill Notation):
C11H10O3
CAS Number:
31005-02-4
Molecular Weight:
190.20
Beilstein:
146200
EC Number:
250-429-4
MDL number:
MFCD00006877
UNSPSC Code:
12161501

grade

for fluorescence

Assay

≥99.0% (HPLC)

mp

88-90 °C (lit.)
90-92 °C

fluorescence

λex 323 nm; λem 386 nm in H2O

SMILES string

CCOc1ccc2C=CC(=O)Oc2c1

InChI

1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3

InChI key

LIFAQMGORKPVDH-UHFFFAOYSA-N

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Biochem/physiol Actions

Substrate for CYP2B6

Other Notes

Substrate for a rapid sensitive fluorometric assay of microsomal monooxygenase activity

replaced by

Product No.
Description
Pricing

E1379

7-Ethoxycoumarin

Regulatory Information

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B C Kunz et al.
FEBS letters, 161(2), 311-314 (1983-09-19)
Cytochrome P450 purified from phenobarbital-induced rat liver microsomes was acetylated at 3 lysyl residues. When reconstituted with purified NADPH-cytochrome P450 reductase, the modified cytochrome showed full activity and substrate-induced spectral changes with d-benzphetamine. With 7-ethoxycoumarin, neither enzymic activity nor binding
W F Greenlee et al.
The Journal of pharmacology and experimental therapeutics, 205(3), 596-605 (1978-06-01)
An improved in vitro fluorometric assay of the O-deethylation of 7-ethoxycoumarin which is at least 10 times more sensitive than existing methods is described. Nearly quantitative recovery of the product which is essentially free of fluorescent impurities is obtained by
Direct fluorometric methods for measuring mixed function oxidase activity.
R A Prough et al.
Methods in enzymology, 52, 372-377 (1978-01-01)
H Rothe et al.
Journal of applied toxicology : JAT, 37(7), 806-816 (2017-02-01)
Partition (K) and diffusion (D) coefficients are important to measure for the modelling of skin penetration of chemicals through the stratum corneum (SC). We compared the feasibility of three protocols for the testing of 50 chemicals in our main studies
Michele Gottardi et al.
Environmental toxicology and chemistry, 36(8), 2155-2166 (2017-02-02)
Two of the main classes of pesticides commonly used in agriculture are azole fungicides and pyrethroid insecticides. Because azoles have been shown to synergize the effect of pyrethroids, the effect of their mixture is of concern. The aim of the
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