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  • Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum.

Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum.

Journal of applied toxicology : JAT (2017-02-01)
H Rothe, C Obringer, J Manwaring, C Avci, W Wargniez, J Eilstein, N Hewitt, R Cubberley, H Duplan, D Lange, C Jacques-Jamin, M Klaric, A Schepky, S Grégoire
PMID28139006
ABSTRACT

Partition (K) and diffusion (D) coefficients are important to measure for the modelling of skin penetration of chemicals through the stratum corneum (SC). We compared the feasibility of three protocols for the testing of 50 chemicals in our main studies, using three cosmetics-relevant model chemicals with a wide range of logP values. Protocol 1: SC concentration-depth profile using tape-stripping (measures K