MABT207
Anti-Integrin alpha-V Antibody, clone 272-17E6 (Azide free)
clone 272-17E6, from mouse
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Synonym(s):
Integrin alpha-V, Vitronectin receptor subunit alpha, CD51, Integrin alpha-V heavy chain, Integrin alpha-V light chain, Intergrin av
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
272-17E6, monoclonal
species reactivity
human
technique(s)
activity assay: suitable
flow cytometry: suitable
immunoprecipitation (IP): suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITGAV(3685)
Related Categories
General description
Integrin alpha-V (or CD51; vitronectin receptor subunit alpha) protein is a transmembrane receptor that mediates adhesion of cells to each other and to the extracellular matrix. Integrin receptors are activated by a variety of intracellular signals that modify its cytoplasmic domain and induce configural changes in integrin molecules thereby enabling ligand binding to the extracellular surface. An important part of this process is the binding of the actin protein, talin, to the integrin cytoplasmic domain.
Immunogen
Human Placental ɑvβ3
Application
Anti-Integrin alpha-V Antibody, clone 272-17E6 (Azide free) detects level of Integrin alpha-V & has been published & validated for use in Flow Cytometry, Immunoprecipitation, Activity Assay.
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to detect Integrin alpha-V in M21 cell lysates. (Mitjans, F., et al (1995). Journal of Cell Science. 108:2825-2838.)
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
Quality
Evaluated by Flow Cytometry in HeLa cells.
Flow Cytometry Analysis: 0.5 µg of this antibody detected Integrin alpha-V in HeLa cells.
Flow Cytometry Analysis: 0.5 µg of this antibody detected Integrin alpha-V in HeLa cells.
Target description
116 kDa calculated
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS without preservative.
Storage and Stability
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
HeLa cells
HeLa cells
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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