MABF158C
Anti-CD152 (CTLA-4) (mouse), PE-Cy7, clone UC10-4F10-11 Antibody
clone UC10-4F10-11, from hamster(Armenian), PE-Cy7
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Synonym(s):
Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), CD152, CD152 (CTLA-4)
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.44
Recommended Products
biological source
hamster (Armenian)
Quality Level
conjugate
PE-Cy7
antibody form
purified antibody
antibody product type
primary antibodies
clone
UC10-4F10-11, monoclonal
species reactivity
mouse
packaging
antibody small pack of 25 μg
technique(s)
flow cytometry: suitable
isotype
IgG
UniProt accession no.
target post-translational modification
unmodified
Gene Information
mouse ... Ctla4(12477)
Related Categories
General description
The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.
Application
This armenian hamster monoclonal Anti-CD152 (CTLA-4) Antibody (mouse), PE-Cy7, clone UC10-4F10-11, Cat. No. MABF1586 is validated for use in Flow Cytometry, for the detection of CD152 (CTLA-4).
Quality
This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.
Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.
Other Notes
Concentration: Please refer to lot specific datasheet.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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