MAB341
Anti-GABA A Receptor β 2,3 Chain Antibody, clone BD17
clone BD17, Chemicon®, from mouse
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Synonym(s):
GABA(A) receptor subunit beta-2, gamma-aminobutyric acid (GABA) A receptor, beta 2, gamma-aminobutyric acid A receptor, beta 2
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
BD17, monoclonal
species reactivity
mouse, feline, monkey, bovine
species reactivity (predicted by homology)
rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... GABRB2(2561)
General description
Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels that mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines.
Specificity
Reacts with the β-chain of the GABAA receptor.
Immunogen
Epitope: Extracellular domain of the beta2 & beta3 subunits of the GABAA receptor
Purified GABA/benzodiazepine receptor from bovine cortex
Application
Detect GABA A Receptor β 2 using this Anti-GABA A Receptor β 2, 3 Chain Antibody, clone BD17 validated for use in IH, IP & WB.
Immunohistochemistry:
A 10-20 μg/mL concetration of a previous lot was used in IH.
Immunoprecipitation:
A previous lot of this antibody was used in IP.
Western blot:
5-20 µg/mL. Recognizes a 55 kDa band corresponding to the beta chain of the GABAA receptor.
Optimal working dilutions must be determined by end user.
A 10-20 μg/mL concetration of a previous lot was used in IH.
Immunoprecipitation:
A previous lot of this antibody was used in IP.
Western blot:
5-20 µg/mL. Recognizes a 55 kDa band corresponding to the beta chain of the GABAA receptor.
Optimal working dilutions must be determined by end user.
Quality
Evaluated by Western Blot on mouse brain membrane lysates.
Western Blot:
1:500 dilution of this antibody detected GABA A Receptor β 2,3 Chain on 10 μg of mouse brain membrane lysates.
Western Blot:
1:500 dilution of this antibody detected GABA A Receptor β 2,3 Chain on 10 μg of mouse brain membrane lysates.
Target description
55 kDa
Linkage
Replaces: AB5952
Physical form
Format: Purified
Purified mouse monoclonal IgG1 liquid in buffer containing 10 mM potassium phosphate buffer pH 7.4 with 150 mM NaCl
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Human ?1?3?2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.
Dostalova, Z; Zhou, X; Liu, A; Zhang, X; Zhang, Y; Desai, R; Forman, SA; Miller, KW
Protein Science null
Daniel C Adusei et al.
Neuropharmacology, 59(3), 167-171 (2010-05-18)
Fragile X syndrome is the most common heritable form of mental retardation. It is caused by silencing of the Fmr1 gene and the absence of the encoded protein. The purpose of this study was to examine global protein expression levels
Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.
Braun, M; Ramracheya, R; Bengtsson, M; Clark, A; Walker, JN; Johnson, PR; Rorsman, P
Diabetes null
Pengju Ma et al.
International journal of clinical and experimental medicine, 8(8), 14296-14302 (2015-11-10)
This study aimed to investigate GABA effects on blood pressure and blood dynamics of anesthetic rats by observing spontaneously hypertensive rats under both anesthesia and waking state. 72 male waking Wistar-Kyokos (WKY) rats and 72 male anesthetized spontaneously hypertensive (SHR)
Mirko Feldmann et al.
Cerebral cortex (New York, N.Y. : 1991), 29(2), 892-905 (2018-12-12)
Although by adulthood cortical structures and their capacity for processing sensory information have become established and stabilized, under conditions of cortical injury, or sensory deprivation, rapid reorganization occurs. Little is known as to the impact of this kind of adaptation
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