GF446
Thermostable bFGF,Human
HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture
Synonym(s):
FGF2, prostatropin, Prostatropin, HBGF-2, BFGF
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About This Item
Product Name
HumanKine® Thermostable bFGF,
Human Recombinant, Engineered bFGF growth factor with enchanced thermostability compared to the wild-type bFGF protein. Allows a less vigorous feeding schedule for human es/ips and neural stem cell culture.
Quality Level
assay
>95% (SDS-PAGE)
manufacturer/tradename
HumanKine®
impurities
<0.5 μg/mg protein endotoxin (<5 EU/μg)
UniProt accession no.
General description
Fibroblast Growth Factor-basic (bFGF) is a heparin binding growth factor which stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal and endothelial cells. bFGF also exerts a potent angiogenic activity in vivo. Human bFGF is a 17.2 kDa protein containing 154 amino acid residues. bFGF synergizes with the BMP antagonist noggin to sustain undifferentiated proliferation of human embryonic stem (hES) cells under feeder-free conditions.
Application
Stem Cell Research
Growth Factors & Receptors
Physical form
Preparation Note
Analysis Note
Legal Information
Disclaimer
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Articles
The Simplicon™ RNA Reprogramming Technology is a next generation reprogramming system that uses a single synthetic, polycistronic self-replicating RNA strand engineered to mimic cellular RNA to generate human iPS cells.
Fibroblast growth factors (FGFs) regulate developmental pathways and mesoderm/ectoderm patterning in early embryonic development.
Related Content
Fibroblast growth factors (FGFs) are secreted glycoproteins that regulate several fundamental developmental pathways and help regulate mesoderm and ectoderm patterning in the early embryonic development. In adults, FGFs participate in several physiological and pathological processes including cell proliferation, cell survival, differentiation, wound healing, and regulation of angiogenesis. The FGF signaling process involves their binding to FGF receptors (FGFR) on the cell surface. Twenty-three different FGFs have been identified that exert their effects through four major types of tyrosine kinase-linked FGFRs that are designated as FGFR1, FGFR2, FGFR3, and FGFR4. Following ligand binding, these receptors undergo dimerization, which results in the activation of their tyrosine kinase domains and intermolecular transphosphorylation.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| GF446-10UG | 04053252975943 |
| GF446-50UG | 04053252975950 |