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Merck
CN

GF305

IFN- γ Protein, Human Recombinant Animal Free

The Interferon gamma (or IFN-γ protein) is an acid-labile interferon produced by CD4 & CD8 T lymphocytes as well as activated NK cells. Manufactured using all non-animal reagents.

Synonym(s):

IFN, Interferon Gamma, IFNG, IFN Gamma

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
eCl@ss:
32160405

Key Documents

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Product Name

IFN- γ Protein, Human Recombinant Animal Free, The Interferon gamma (or IFN-γ protein) is an acid-labile interferon produced by CD4 & CD8 T lymphocytes as well as activated NK cells. Manufactured using all non-animal reagents.

assay

>98% (SDS-PAGE and HPLC)

impurities

<0.1 μg/mg protein endotoxin (<1EU/μg)

NCBI accession no.

NM_000619.2

UniProt accession no.

P01579

shipped in

dry ice

Quality Level

100

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Analysis Note

Bioactivity assay: Determined by its ability to induce apoptosis in HeLa cells. The expected ED50 for this effect is 5.0-10.0 ng/ml.

General description

Interferon gamma (IFN-γ) is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.7 kDa protein containing 143 amino acid residues.

Physical form

Recombinant animal free human IFN- γ is manufactured using all non-animal reagents

Storage Class

11 - Combustible Solids

wgk

WGK 1

Certificates of Analysis (COA)

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