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Key Documents

ABE208

Sigma-Aldrich

Anti-β-Catenin Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

catenin (cadherin-associated protein), beta 1, 88kDa, catenin (cadherin-associated protein), beta 1 (88kD)

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100 EA
¥152.46

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

¥152.46

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biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human, rat, horse

species reactivity (predicted by homology)

ox (based on 100% sequence homology), equine (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NP_001895

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854142

带 PTFE/橡胶隔垫的 11mm 钳口密封盖

material

PTFE-faced rubber septum, silver aluminum seal

material

PTFE/red rubber septum

material

PTFE/red rubber septum, gold aluminum seal

material

green aluminum seal, septum (TFE/butyl/red rubber)

fitting

thread for 11 mm

fitting

-

fitting

closure for 11 mm crimp top vial

fitting

thread for 11 mm

feature

closure type crimp seal

feature

-

feature

closure type crimp seal

feature

closure type crimp seal

packaging

pkg of 100 ea

packaging

pkg of 100 ea

packaging

pkg of 1000 ea

packaging

pkg of 1000 ea

seal diam.

11 mm

seal diam.

11 mm

seal diam.

11 mm

seal diam.

-

General description

β-catenin is the founding member of the β -catenin family. This protein is comprised of 12 ARM repeats and is considered to have dual function depending on its localization. Cytoplasmic β -catenin is a critical component of E-cadherin/catening adhesion complexes and is involved in regulating cadherin-dependent cell-cell interactions.When localized to the nucleus, β -catenin serves a regulatory role by binding with transcription factors from the TCF/LEF family, activating transcription. Expression of β -catenin has been reported in a variety of hair follicle cells such as cells found in the inner and outer portions of the root sheaths, and the basal and peripheral matrix cells. It has also been observed in colon tissue. Defects in expression have been linked to the development of several tumors and cancers such as; colorectal cancer (CRC), medulloblastoma (MDB), ovarian cancer (OC), and pilomatrixoma (PTR).

Specificity

Antibody recognizes β-Catenin at the N-terminus.

Immunogen

Epitope: Consensus GSK3 phosphorylation site of human β-Catenin
KLH-conjugated linear peptide corresponding to the consensus GSK3 phosphorylation site of human β-Catenin.

Application

Anti-β-Catenin Antibody is a Rabbit Polyclonal Antibody for detection of β-Catenin also known as catenin (cadherin-associated protein) beta 1 (88kD) & has been validated in WB, ICC & IP.
Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated β-Catenin from A431 lysate.

Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected β-Catenin in NIH/3T3 and A431 cells.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Quality

Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: 0.05 µg/mL of this antibody detected β-Catenin on 10 µg of A431 cell lysate.

Target description

~86kDa observed.

Linkage

Replaces: 04-1002

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
A431 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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