AB2295
Anti-phospho GluR4 (Ser842) Antibody
from rabbit, purified by affinity chromatography
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glutamate receptor, AMPA 4, Glutamate receptor ionotropic, AMPA 4, AMPA-selective glutamate receptor 4, glutamate receptor 4, GluR-D, GluR-4, Glutamate receptor 4
Recommended Products
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat
species reactivity (predicted by homology)
human (based on 100% sequence homology), mouse (based on 100% sequence homology)
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pSer842)
Gene Information
human ... GRIA4(2893)
General description
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. GluR4 is an ionotropic glutamate receptor encoded by the GRIA4 gene. Alternative splicings of this gene result in transcript variants encoding different isoforms, which are believed to vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. Direct phosphorylation of GluR4-containing receptors may regulate rapid excitatory synaptic transmission. In particular, phosphorylation of GluR4 at Serine 842 is both necessary and sufficient to deliver the receptor to the synapse and induce plasticity in early postnatal development.
Specificity
This antibody recognizes GluR4 when phosphorylated at Ser842.
Immunogen
Epitope: Phosphorylated Ser842
Linear peptide corresponding to rat GluR4 phosphorylated at Ser842.
Application
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
This Anti-phospho GluR4 (Ser842) Antibody is validated for use in WB for the detection of phospho GluR4 (Ser842).
Quality
Evaluated by Western Blot in phosphatase treated and untreated rat cerebellum tissue lysates.
Western Blot Analysis: 0.5 µg/mL of this antibody detected GluR4 on 10 µg of phosphatase treated and untreated rat cerebellum tissue lysates.
Western Blot Analysis: 0.5 µg/mL of this antibody detected GluR4 on 10 µg of phosphatase treated and untreated rat cerebellum tissue lysates.
Target description
~101 kDa observed. An uncharacterized band may be visible at ~39 kDa in some lysates.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Phosphatase treated and untreated rat cerebellum tissue lysates
Phosphatase treated and untreated rat cerebellum tissue lysates
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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