AB2212
Anti-phospho GluR4 (S862) Antibody
serum, Chemicon®
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UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pSer862)
Gene Information
human ... GRIA4(2893)
General description
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. Direct phosphorylation of GluR4-containing receptors may regulate rapid excitatory synaptic transmission. In addition, phosphorylation of GluR4 S862. is both necessary and sufficient to deliver the receptor to the synapse and induce plasticity in early postnatal development.
Specificity
Cat. # AB2212 recognzies phospho GluR4 (S862).
May react with mouse, human, primate and dog based on sequence homology. Reactivity with other species has not been tested.
Immunogen
Synthetic peptide from rat.
Application
Anti-phospho GluR4 (S862) Antibody is an antibody against phospho GluR4 (S862) for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
Western Blot Analysis:
Cat. # AB2212 recognizes pGluR4 (S862) at 1:5,000 in rat brain cerebellum Lysate.
Cat. # AB2212 recognizes pGluR4 (S862) at 1:5,000 in rat brain cerebellum Lysate.
Quality
Routinely tested on rat brain cerebellum lysate.
Target description
~105 kDa
Physical form
Serum with 0.05% NaN3
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
Analysis Note
Control
Rat Brain Cerebellum lysate
Rat Brain Cerebellum lysate
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Certificates of Analysis (COA)
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Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
Caba?ero, D; Baker, A; Zhou, S; Hargett, GL; Irie, T; Xia, Y; Beaudry, H; Gendron et al.
Neuropsychopharmacology null
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