AB2200
Anti-PRG4 Antibody
from rabbit, purified by affinity chromatography
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All Photos(2)
Synonym(s):
Megakaryocyte-stimulating factor, Superficial zone proteoglycan, articular superficial zone protein, bG174L6.2 (MSF: megakaryocyte stimulating factor ), megakaryocyte stimulating factor, proteoglycan 4, proteoglycan 4, (megakaryocyte stimulating factor,
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse
species reactivity (predicted by homology)
human, rat, primate, horse
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... PRG4(10216)
General description
PRG4, Proteoglycan 4, is a human gene and is found in synovial tissue, cartilage, and liver. Small amounts are found in the lung. Isoform 1 is found in the kidney, lung, liver, heart and brain. The other Isoforms, C & D, are widely expressed. PRG4 is a lubricating glycoprotein containing chondroitin sulfate and keratan sulfate glycosaminoglycans. It is responsible for boundary lubrication at the cartilage surface. A disease associated with PRG4 is Jacobs’s syndrome which is an autosomal recessive disorder.
Specificity
Cat. # AB2220 recognizes PRG4.
Immunogen
Epitope: C-Teminus
KLH-conjugated followed by PRG4 corresponding to the C-terminal region
Application
Anti-PRG4 Antibody is an antibody against PRG4 for use in WB & IC.
Immunocytochemistry:
Confocal IF analysis of N1E-115 using anti-PRG4 (1:500) Rabbit pAB (Red). Actin filaments have been labeled with Alexa Fluor 488 -Phalloidin (Green). Nuclear is stained with DAPI (Blue).
Confocal IF analysis of N1E-115 using anti-PRG4 (1:500) Rabbit pAB (Red). Actin filaments have been labeled with Alexa Fluor 488 -Phalloidin (Green). Nuclear is stained with DAPI (Blue).
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Quality
Western Blotting
Target description
~37 kDa
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Storage and Stability
Stable for 1 year at 2-8ºC from date of receipt.
Analysis Note
Control
Mouse Brain lysates
Mouse Brain lysates
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
recommended
Product No.
Description
Pricing
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Shouan Zhu et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 37(12), 2531-2547 (2022-10-11)
Understanding how obesity-induced metabolic stress contributes to synovial joint tissue damage is difficult because of the complex role of metabolism in joint development, maintenance, and repair. Chondrocyte mitochondrial dysfunction is implicated in osteoarthritis (OA) pathology, which motivated us to study
Kosuke Oikawa et al.
Biomedical reports, 19(3), 60-60 (2023-08-24)
Suppression of the antitumor cytokine interleukin-24 (IL-24) is critical for the survival of myxoid liposarcoma (MLS) cells. It has been previously demonstrated by the authors that an MLS-specific chimeric oncoprotein, translocated in liposarcoma-CCAAT/enhancer-binding protein homologous protein (TLS-CHOP), supresses IL24 mRNA
Y Asakawa-Tanne et al.
Journal of dental research, 94(2), 337-343 (2014-12-17)
Synovial fluid of the joint decreases friction between the cartilage surfaces and reduces cartilage wear during articulation. Characteristic changes of synovial fluid have been shown in patients with osteoarthritis (OA) in the temporomandibular joint (TMJ). OA is generally considered to
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