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AB10514P

Sigma-Aldrich

Anti-Serotonin Transporter Antibody

1 mg/mL, from rabbit

Synonym(s):

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, sodium-dependent serotonin transporter, serotonin transporter, Solute carrier family 6 member 4, Na+/Cl- dependent serotonin transporter, 5HT transporter, 5-hydroxytryptamine tr

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity (predicted by homology)

sheep (100% homology), rat (100% homology), bovine (100% homology), monkey (100% homology), human (100% homology), horse (100% homology), mouse (100% homology), chimpanzee (100% homology)

concentration

1 mg/mL

technique(s)

western blot: suitable

UniProt accession no.

P31645

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... HTT(3064)

Related Categories

General description

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Specificity

Other species have not been tested.
The antibody reacts with the 70 kDa serotonin transporter protein.

Immunogen

Epitope: Center region
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human serotonin transporter.

Application

Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
This Anti-Serotonin Transporter Antibody is validated for use in WB for the detection of Serotonin Transporter.

Quality

Western Blot Analysis: 1:1000 dilution of this antibody detected serotonin transporter on human lung lysate.

Target description

70 kDa

Linkage

Replaces: AB1594P

Physical form

Antigen Affinity Purified
Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

Storage and Stability

Store at 2-8°C for 1 year from date of receipt.

Analysis Note

Control
Western Blot : Human lung lysate.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nune Darbinian et al.
Cells, 13(1) (2024-01-11)
Children with fetal alcohol spectrum disorders (FASD) exhibit behavioral and affective dysregulation, including hyperactivity and depression. The mechanisms are not known, but they could conceivably be due to postnatal social or environmental factors. However, we postulate that, more likely, the
Laura Goetzl et al.
Frontiers in pharmacology, 13, 837694-837694 (2022-04-26)
Patient and providers' fear of fetal exposure to medications may lead to discontinuation of treatment, disease relapse, and maternal morbidity. Placental drug transporters play a critical role in fetal exposure through active transport but the majority of data are limited
Nune Darbinian et al.
International journal of molecular sciences, 25(11) (2024-06-19)
Fetal alcohol spectrum disorders (FASDs) are leading causes of neurodevelopmental disability but cannot be diagnosed early in utero. Because several microRNAs (miRNAs) are implicated in other neurological and neurodevelopmental disorders, the effects of EtOH exposure on the expression of these
Raquel Romay-Tallon et al.
Biomarker research, 5, 27-27 (2017-10-12)
The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depression. Here we evaluated the possibility of performing a similar
Raquel Romay-Tallon et al.
Frontiers in pharmacology, 9, 1149-1149 (2018-10-31)
Naïve depression patients show alterations in serotonin transporter (SERT) and serotonin 2A (5HT2A) receptor clustering in peripheral lymphocytes, and these alterations have been proposed as a biomarker of therapeutic efficacy in major depression. Repeated corticosterone (CORT) induces a consistent depression-like

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